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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May 2012 Volume 5 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients

  • Authors:
    • Yanjie Xia
    • Yena Che
    • Xinlin Zhang
    • Chengwei Zhang
    • Yunxia Cao
    • Wenjun Wang
    • Pei Xu
    • Xiaoke Wu
    • Long Yi
    • Qian Gao
    • Yong Wang

  • View Affiliations / Copyright

    Affiliations: Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, P.R. China, Department of Obstetrics and Gynecology, Anhui Medical University, Hefei 230022, P.R. China, Centre of Reproduction, Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, P.R. China, Department of Obstetrics and Gynecology, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, P.R. China
  • Pages: 1330-1334
    |
    Published online on: February 13, 2012
       https://doi.org/10.3892/mmr.2012.789
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Abstract

Human androgen receptor (AR) contains a highly polymorphic polyglutamine tract encoded by CAG repeats [(CAG)n] in exon 1 of the AR gene. The CAG repeats, ranging from 11 to 38, have been reported to be inversely correlated with AR activity. A case-control study involving 261 polycystic ovary syndrome (PCOS) patients and 278 healthy controls was conducted. Fluorescently labeled DNA fragments containing (CAG)n were obtained by PCR and genotyped via capillary electrophoresis. AR (CAG)n ranges were 6, 12-28 in PCOS cases and 9, 10, 12-32 in controls. In the PCOS group, a higher frequency of short (CAG)n alleles was found compared with that of controls (P=0.007). Similarly, CAG biallelic mean distributions also showed statistical difference between the two groups (P=0.025). In conclusion, shorter alleles of the (CAG)n in exon 1 of the AR gene enhanced the susceptibility to PCOS, either by upregulating AR activity or by causing hyperandrogenism.

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Copy and paste a formatted citation
Spandidos Publications style
Xia Y, Che Y, Zhang X, Zhang C, Cao Y, Wang W, Xu P, Wu X, Yi L, Gao Q, Gao Q, et al: Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients. Mol Med Rep 5: 1330-1334, 2012.
APA
Xia, Y., Che, Y., Zhang, X., Zhang, C., Cao, Y., Wang, W. ... Wang, Y. (2012). Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients. Molecular Medicine Reports, 5, 1330-1334. https://doi.org/10.3892/mmr.2012.789
MLA
Xia, Y., Che, Y., Zhang, X., Zhang, C., Cao, Y., Wang, W., Xu, P., Wu, X., Yi, L., Gao, Q., Wang, Y."Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients". Molecular Medicine Reports 5.5 (2012): 1330-1334.
Chicago
Xia, Y., Che, Y., Zhang, X., Zhang, C., Cao, Y., Wang, W., Xu, P., Wu, X., Yi, L., Gao, Q., Wang, Y."Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients". Molecular Medicine Reports 5, no. 5 (2012): 1330-1334. https://doi.org/10.3892/mmr.2012.789
Copy and paste a formatted citation
x
Spandidos Publications style
Xia Y, Che Y, Zhang X, Zhang C, Cao Y, Wang W, Xu P, Wu X, Yi L, Gao Q, Gao Q, et al: Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients. Mol Med Rep 5: 1330-1334, 2012.
APA
Xia, Y., Che, Y., Zhang, X., Zhang, C., Cao, Y., Wang, W. ... Wang, Y. (2012). Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients. Molecular Medicine Reports, 5, 1330-1334. https://doi.org/10.3892/mmr.2012.789
MLA
Xia, Y., Che, Y., Zhang, X., Zhang, C., Cao, Y., Wang, W., Xu, P., Wu, X., Yi, L., Gao, Q., Wang, Y."Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients". Molecular Medicine Reports 5.5 (2012): 1330-1334.
Chicago
Xia, Y., Che, Y., Zhang, X., Zhang, C., Cao, Y., Wang, W., Xu, P., Wu, X., Yi, L., Gao, Q., Wang, Y."Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients". Molecular Medicine Reports 5, no. 5 (2012): 1330-1334. https://doi.org/10.3892/mmr.2012.789
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