Molecular Medicine Reports Special Issues

The regulation and function of gene transcription and protein post-translational modification on tumorigenesis, progression and drug

Lead Editor:

    Dr Dejie Wang
    mayo clinic
    United States

Abnormal gene transcription often leads to human diseases, such as cancer. Moreover, dysregulation of the functions of transcription regulatory proteins by mechanisms such as phosphorylation, acetylation, ubiquitination, methylation, and protein-protein initiates and develops many types of cancers. Deep understanding of these processes will not only shed new light on the etiology of cancer but also may lead to identifying novel targets for diagnostics, prognostics and therapeutics for those lethal diseases.

Clinical utility of liquid biopsies as diagnostic or prognostic tools for cancer

Lead Editor:

    Dr Emmanouil Karteris
    Brunel University
    United Kingdom

Liquid biopsies offer a promising alternative to tissue samples, providing non-invasive diagnostic approaches or serial monitoring of disease evolution. However, certain challenges remain, and the full potential of liquid biopsies has yet to be reached. In this Special Issue, we will invite clinical and basic scientists to showcase their latest research in this field.

Direct oral anticoagulants for cancer-associated venous thromboembolism in Japan

Lead Editor:

    Dr Yoshinori Imamura
    Kobe University Hospital

Cancer-associated venous thromboembolism is a severe and potentially fatal event. Over the past few years, results from several randomized control trials have been published, and direct oral anticoagulants are becoming new standard care for this disease in addition to low molecular weight heparins. Although Japanese patients have seldom participated in these trials, direct oral anticoagulants are widely used in current practice, especially because low molecular weight heparins have not been approved for acute venous thromboembolism in Japan. Since the “East Asian paradox” meant a unique risk-benefit compromise, less anti-ischemic benefits and more risk of bleeding during antithrombotic therapies compared with Caucasian patients, direct extrapolation of Caucasian data to Japanese could be inappropriate. Polymorphisms among anticoagulant factors, cytochrome P450 metabolisms, and ATP-binding cassette transporters may be important biological factors to explain the ethnic disparity. This special issue will focus on the current evidence and future directions of direct oral anticoagulants for cancer-associated venous thromboembolism in Japanese patients.

Pharmacologic Chaperone

Lead Editor:

    Professor Seong-Gon Kim
    Gangneung-Wonju National University
    Republic of Korea

Chaperone is used for alleviating stress from the environment. Chaperone can improve the survival rate of organism. Using chaperone, there have been many trials to treat the challenging diseases. This special issue aims to collect the articles about molecular mechanism of pharmacologic chaperone, target disease for pharmacologic chaperone, and clinical application of pharmacologic chaperone.

Journal Cover

Volume 26 Issue 3

Print ISSN: 1791-2997
Online ISSN: 1791-3004

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