Biological similarities between murine chemical-induced and natural human bladder carcinogenesis

  • Authors:
    • Carlos Palmeira
    • Paula A. Oliveira
    • Catarina Lameiras
    • Teresina Amaro
    • Victor M. Silva
    • Carlos Lopes
    • Lúcio Santos
  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/ol_00000066
  • Pages: 373-377
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Abstract

The present study investigated the similarities between rodent and human urothelial carcinogenesis models using DNA content, p53 and Ki-67 immunoexpression as surrogate markers of bladder carcinogenesis. Following N-butyl-N-(4-hydroxybutyl)-nitrosamine exposure, 49 human cystectomy specimens of bladder cancer and 53 rat bladder specimens were studied. All of the tumours and adjacent mucosa present in each specimen were evaluated. High similarities were observed between the rodent urothelium carcinogenesis process and the corresponding process in humans, in regards to the histopathological features and biological alteration profile: DNA aneuploidy, p53 overexpression and high proliferative index measured by Ki-67 immunoexpression. Despite these similarities, a higher frequency of alterations was observed in earlier stages in the rat chemical-induced carcinogenesis, namely in 5c aneuploid cells, p53 overexpression and higher Ki-67 labelling index. These results confirm that this experimental animal model is a suitable and reproducible model of bladder carcinogenesis, particularly in regards to high-risk non-invasive and invasive urothelial carcinomas. These features mandate its use in the identification of new molecular targets and evaluation of tumour response to new cytotoxic drugs or drug combinations in bladder cancer therapeutic intervention.
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March-April 2010
Volume 1 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Palmeira C, Oliveira PA, Lameiras C, Amaro T, Silva VM, Lopes C and Santos L: Biological similarities between murine chemical-induced and natural human bladder carcinogenesis . Oncol Lett 1: 373-377, 2010.
APA
Palmeira, C., Oliveira, P.A., Lameiras, C., Amaro, T., Silva, V.M., Lopes, C., & Santos, L. (2010). Biological similarities between murine chemical-induced and natural human bladder carcinogenesis . Oncology Letters, 1, 373-377. https://doi.org/10.3892/ol_00000066
MLA
Palmeira, C., Oliveira, P. A., Lameiras, C., Amaro, T., Silva, V. M., Lopes, C., Santos, L."Biological similarities between murine chemical-induced and natural human bladder carcinogenesis ". Oncology Letters 1.2 (2010): 373-377.
Chicago
Palmeira, C., Oliveira, P. A., Lameiras, C., Amaro, T., Silva, V. M., Lopes, C., Santos, L."Biological similarities between murine chemical-induced and natural human bladder carcinogenesis ". Oncology Letters 1, no. 2 (2010): 373-377. https://doi.org/10.3892/ol_00000066