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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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January-2016 Volume 11 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Pretreatment levels of serum osteoprotegerin and p53 protein and urine telomerase as prognostic factors affecting survival in Egyptian bladder cancer patients

  • Authors:
    • Rania Bakry
    • Mohamed I. El‑Sayed
    • Hesham M. Hamza
    • Khaled H. Hassan

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut 71111, Egypt, Department of Radiotherapy, South Egypt Cancer Institute, Assiut University, Assiut 71111, Egypt, Department of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Assiut 71111, Egypt, Department of Biochemistry, Faculty of Pharmacy (Boys), Al‑Azhar University, Cairo 11566, Egypt
  • Pages: 823-830
    |
    Published online on: November 17, 2015
       https://doi.org/10.3892/ol.2015.3925
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Abstract

A non-invasive marker is required for the diagnosis and follow-up of patients with bladder cancer. The aim of the current study was to evaluate the potential prognostic significance of serum osteoprotegerin (OPG), p53 protein and urine telomerase in patients with bladder cancer. For all patients, serum levels of OPG and p53 protein were determined using enzyme‑linked immunosorbent assay (ELISA), and urine telomerase was assessed using a polymerase chain reaction ELISA technique. Patients were assigned into group 1 (cystectomy and adjuvant radiotherapy) or group 2 (transurethral resection and chemoradiotherapy). The results revealed that serum OPG and p53, and urine telomerase levels were significantly higher in bladder cancer patients compared with in healthy individuals (P<0.0001). High serum OPG was associated with significantly lower overall survival and disease‑free survival rates (both P=0.001), and was correlated with advanced tumor stages (P<0.0001), high tumor grades (P<0.0001) and the occurrence of disease relapse (P=0.001). Serum p53 and urine telomerase did not demonstrate prognostic significance. These findings indicate that serum OPG level may be used as a diagnostic tool and a prognostic variable for patients with muscle invasive bladder cancer. Future trials are required to elucidate its therapeutic role in such patients.

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Copy and paste a formatted citation
Spandidos Publications style
Bakry R, El‑Sayed MI, Hamza HM and Hassan KH: Pretreatment levels of serum osteoprotegerin and p53 protein and urine telomerase as prognostic factors affecting survival in Egyptian bladder cancer patients. Oncol Lett 11: 823-830, 2016.
APA
Bakry, R., El‑Sayed, M.I., Hamza, H.M., & Hassan, K.H. (2016). Pretreatment levels of serum osteoprotegerin and p53 protein and urine telomerase as prognostic factors affecting survival in Egyptian bladder cancer patients. Oncology Letters, 11, 823-830. https://doi.org/10.3892/ol.2015.3925
MLA
Bakry, R., El‑Sayed, M. I., Hamza, H. M., Hassan, K. H."Pretreatment levels of serum osteoprotegerin and p53 protein and urine telomerase as prognostic factors affecting survival in Egyptian bladder cancer patients". Oncology Letters 11.1 (2016): 823-830.
Chicago
Bakry, R., El‑Sayed, M. I., Hamza, H. M., Hassan, K. H."Pretreatment levels of serum osteoprotegerin and p53 protein and urine telomerase as prognostic factors affecting survival in Egyptian bladder cancer patients". Oncology Letters 11, no. 1 (2016): 823-830. https://doi.org/10.3892/ol.2015.3925
Copy and paste a formatted citation
x
Spandidos Publications style
Bakry R, El‑Sayed MI, Hamza HM and Hassan KH: Pretreatment levels of serum osteoprotegerin and p53 protein and urine telomerase as prognostic factors affecting survival in Egyptian bladder cancer patients. Oncol Lett 11: 823-830, 2016.
APA
Bakry, R., El‑Sayed, M.I., Hamza, H.M., & Hassan, K.H. (2016). Pretreatment levels of serum osteoprotegerin and p53 protein and urine telomerase as prognostic factors affecting survival in Egyptian bladder cancer patients. Oncology Letters, 11, 823-830. https://doi.org/10.3892/ol.2015.3925
MLA
Bakry, R., El‑Sayed, M. I., Hamza, H. M., Hassan, K. H."Pretreatment levels of serum osteoprotegerin and p53 protein and urine telomerase as prognostic factors affecting survival in Egyptian bladder cancer patients". Oncology Letters 11.1 (2016): 823-830.
Chicago
Bakry, R., El‑Sayed, M. I., Hamza, H. M., Hassan, K. H."Pretreatment levels of serum osteoprotegerin and p53 protein and urine telomerase as prognostic factors affecting survival in Egyptian bladder cancer patients". Oncology Letters 11, no. 1 (2016): 823-830. https://doi.org/10.3892/ol.2015.3925
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