Identification and frequency of the rs12516 and rs8176318 BRCA1 gene polymorphisms among different populations

  • Authors:
    • Fang Yang
    • Fengxia Chen
    • Jin Xu
    • Xiaoxiang Guan
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  • Published online on: February 19, 2016     https://doi.org/10.3892/ol.2016.4252
  • Pages: 2481-2486
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Abstract

Genetic mutation of breast cancer 1 (BRCA1) is one of the most notable factors responsible for a proportion of breast cancer cases. BRCA1 encodes a 1,863‑amino acid protein and functions as a negative regulator of tumor growth. Thus, investigation of the underlying mechanisms that regulate BRCA1 gene expression provide further insight into possible targets for breast cancer therapy. Previous studies have demonstrated that the genetic variants in the BRCA1 3' untranslated region (3'UTR), in addition to the cytosine‑phosphate‑guanine (CpG) islands in the promoter region, are significantly associated with breast cancer risk; however, the role of single nucleotide polymorphisms (SNPs) in the BRCA1 3'UTR remains unclear. The present study aimed to investigate the association between SNPs and BRCA1 mRNA expression levels. Bioinformatics analysis demonstrated that 2 SNPs in the BRCA1 3'UTR (rs12516 and rs8176318 with putative microRNA binding sites) were significantly correlated with mRNA expression in lymphoblastoid cell lines (P=2.55x10‑4 and P=8.78x10‑5, respectively). Furthermore, the genotype frequency distribution varied between populations worldwide. In addition, 3 CpG islands and several transcription factor binding sites in the BRCA1 promoter region were established. The identification of such polymorphisms and CpG islands may aid in designing improved therapeutic strategies to treat patients with BRCA1-associated breast cancer.
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April-2016
Volume 11 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yang F, Chen F, Xu J and Guan X: Identification and frequency of the rs12516 and rs8176318 BRCA1 gene polymorphisms among different populations. Oncol Lett 11: 2481-2486, 2016.
APA
Yang, F., Chen, F., Xu, J., & Guan, X. (2016). Identification and frequency of the rs12516 and rs8176318 BRCA1 gene polymorphisms among different populations. Oncology Letters, 11, 2481-2486. https://doi.org/10.3892/ol.2016.4252
MLA
Yang, F., Chen, F., Xu, J., Guan, X."Identification and frequency of the rs12516 and rs8176318 BRCA1 gene polymorphisms among different populations". Oncology Letters 11.4 (2016): 2481-2486.
Chicago
Yang, F., Chen, F., Xu, J., Guan, X."Identification and frequency of the rs12516 and rs8176318 BRCA1 gene polymorphisms among different populations". Oncology Letters 11, no. 4 (2016): 2481-2486. https://doi.org/10.3892/ol.2016.4252