Statistics and outlook of primary hepatic angiosarcoma based on clinical stage

Huang,I‑Hsuan; Wu,Yi‑Ying; Huang,Tzu‑Chuan; Chang,Wei‑Kuo; Chen,Jia‑Hong

doi:10.3892/ol.2016.4348

Statistics and outlook of primary hepatic angiosarcoma based on clinical stage

Authors:
- I‑Hsuan Huang
- Yi‑Ying Wu
- Tzu‑Chuan Huang
- Wei‑Kuo Chang
- Jia‑Hong Chen
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Affiliations: Department of Medicine, Tri‑Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan R.O.C., Division of Hematology and Oncology, Tri‑Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan R.O.C., Division of Gastroenterology, Tri‑Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan R.O.C.
Published online on: March 17, 2016 https://doi.org/10.3892/ol.2016.4348
Pages: 3218-3222

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Abstract

Hepatic angiosarcoma is a rare condition that has been associated with exposure to colloidal solutions of thorium dioxide, vinyl chloride, arsenic and radiation. Therapeutic guidelines have not been definitively established due to the small number of cases of this disease. The present study reviewed 28 cases of hepatic angiosarcoma from studies that had been published between January 2000 and December 2012, in addition to 6 cases diagnosed at Tri-Service General Hospital (Taipei, Taiwan). Clinical staging was based on American Joint Committee on Cancer staging system for soft tissue sarcoma (2014). With a mean follow‑up of 27.5 months (range, 0.27‑102 months), 18% (6/34) of the patients survived. The 1‑, 3‑ and 5‑year survival rates were 68.0±9.3, 42.1±10.2 and 32.7±9.8% for patients with stage I disease (mean follow‑up, 32.7 months), whilst the 1‑ and 3‑year survival rates were 33.3±15.7 and 22.2±13.9% for patients with stage IV disease (mean follow‑up, 13.0 months). Determining an appropriate therapeutic strategy for this patient group is necessary. New studies encompassing larger patient populations are required in order to analyze and define standard prognostic parameters and to standardize a treatment approach for this extremely rare neoplasm.

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