Open Access

Expression of microRNA‑181 determines response to treatment with azacitidine and predicts survival in elderly patients with acute myeloid leukaemia

  • Authors:
    • Aleksandra Butrym
    • Justyna Rybka
    • Dagmara Baczyńska
    • Rafał Poręba
    • Grzegorz Mazur
    • Kazimierz Kuliczkowski
  • View Affiliations

  • Published online on: August 8, 2016     https://doi.org/10.3892/ol.2016.4970
  • Pages: 2296-2300
  • Copyright: © Butrym et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRs) are small non‑coding RNAs that play important roles in cell differentiation and survival. Abnormal expression of miRs has been demonstrated in numerous types of cancer, including acute myeloid leukaemia (AML). The aim of the present study was to evaluate miR‑181 expression at diagnosis and following the completion of chemotherapy in AML patients, with regard to clinical response and outcome, particularly in patients treated with azacitidine. miR‑181 expression was analysed using reverse transcription‑quantitative polymerase chain reaction in 95 bone marrow specimens from newly diagnosed AML patients and in 20 healthy subjects for comparison. The results revealed upregulated miR‑181 expression in the total cohort of AML patients, which was correlated with longer survival. However, in a subset of older AML patients treated with azacitidine, low miR‑181 expression at diagnosis was a predictor for complete remission and prolonged survival. The findings indicated that miR‑181 has an important role in AML and determines response to azacitidine treatment in older AML patients.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Butrym A, Rybka J, Baczyńska D, Poręba R, Mazur G and Kuliczkowski K: Expression of microRNA‑181 determines response to treatment with azacitidine and predicts survival in elderly patients with acute myeloid leukaemia. Oncol Lett 12: 2296-2300, 2016
APA
Butrym, A., Rybka, J., Baczyńska, D., Poręba, R., Mazur, G., & Kuliczkowski, K. (2016). Expression of microRNA‑181 determines response to treatment with azacitidine and predicts survival in elderly patients with acute myeloid leukaemia. Oncology Letters, 12, 2296-2300. https://doi.org/10.3892/ol.2016.4970
MLA
Butrym, A., Rybka, J., Baczyńska, D., Poręba, R., Mazur, G., Kuliczkowski, K."Expression of microRNA‑181 determines response to treatment with azacitidine and predicts survival in elderly patients with acute myeloid leukaemia". Oncology Letters 12.4 (2016): 2296-2300.
Chicago
Butrym, A., Rybka, J., Baczyńska, D., Poręba, R., Mazur, G., Kuliczkowski, K."Expression of microRNA‑181 determines response to treatment with azacitidine and predicts survival in elderly patients with acute myeloid leukaemia". Oncology Letters 12, no. 4 (2016): 2296-2300. https://doi.org/10.3892/ol.2016.4970