Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion

Hoellen,Friederike; Waldmann,Annika; Banz‑Jansen,Constanze; Rody,Achim; Heide,Maria; Köster,Frank; Ribbat‑Idel,Julika; Thorns,Christoph; Gebhard,Maximilian; Oberländer,Martina; Habermann,Jens K.; Thill,Marc

doi:10.3892/ol.2016.4925

Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion

Authors:
- Friederike Hoellen
- Annika Waldmann
- Constanze Banz‑Jansen
- Achim Rody
- Maria Heide
- Frank Köster
- Julika Ribbat‑Idel
- Christoph Thorns
- Maximilian Gebhard
- Martina Oberländer
- Jens K. Habermann
- Marc Thill
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Affiliations: Department of Gynecology and Obstetrics, University of Lübeck and University Hospital Schleswig‑Holstein, Lübeck Campus, Lübeck D-23538, Germany, Institute for Social Medicine and Epidemiology, University of Lübeck, Lübeck D-23538, Germany, Institute for Pathology, University of Lübeck, Lübeck D-23538, Germany, Institute for Pathology, Hamburg D-22339, Germany, Department of Surgery, Section for Translational Surgical Oncology and Biobanking, University of Lübeck and University Hospital Schleswig‑Holstein, Lübeck Campus, Lübeck D-23562, Germany, Department of Gynecology and Obstetrics, Agaplesion Markus Hospital, Frankfurt D-60431, Germany
Published online on: July 29, 2016 https://doi.org/10.3892/ol.2016.4925
Pages: 2351-2356
Copyright: © Hoellen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. The current study analyzed the effect of COX‑2 expression in patients with invasive squamous cervical cancer. Tissue samples from 123 cervical cancer patients were collected for a retrospective analysis using immunohistochemistry (IHC) with an antibody against COX‑2. The clinical and survival data of the patients were analyzed. Positive staining for COX‑2 (defined as an immunoreactivity score of ≥4) was detected in 28 patients (23%), with significantly higher percentages of staining in tumor cells compared with peritumoral stroma cells (P<0.001). COX‑2 expression was significantly associated with lymphovascular space invasion (LVSI; P=0.017). The association of COX‑2 expression with LVSI suggests a possible effect of COX‑2 on tumor progression in cervical cancer. Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival.

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