Misdiagnosed infantile rhabdomyofibrosarcoma: A case report

  • Authors:
    • Tao Pan
    • Ken Chen
    • Run‑Song Jiang
    • Zheng‑Yan Zhao
  • View Affiliations

  • Published online on: August 17, 2016     https://doi.org/10.3892/ol.2016.5032
  • Pages: 2766-2768
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Abstract

Infantile rhabdomyofibrosarcoma is a rare form of soft-tissue tumor often associated with difficulties in diagnosis. The disease is positioned intermediately between rhabdomyosarcoma and infantile fibrosarcoma in terms of clinical presentation, immunohistochemistry, behavior, morphology and ultrastructural features. Reports of rhabdomyofibrosarcoma cases are limited in the literature. The present case describes a 26‑month‑old female who presented with a slowly progressive, soft‑tissue mass in the right chest wall. The mass was successfully treated with surgery. Using histopathology, the tumor was diagnosed and classified as infantile rhabdomyofibrosarcoma. The patient has been followed‑up for 2 years and is currently in good condition. The present case demonstrates that early, radical, local surgery and multidisciplinary cooperation were successful for the treatment of rhabdomyofibrosarcoma, and close follow‑up highly recommended.

Introduction

Spindle cell tumors are a rare form of neoplasm that are often difficult to diagnose, with benign lesions occasionally exhibiting malignant and infiltrative features (1). Infantile rhabdomyofibrosarcoma is positioned intermediately between truculent spindle cell rhabdomyosarcoma and indolent, infantile fibrosarcoma in terms of clinical presentation, immunohistochemistry, behavior, morphology and ultrastructural features (2). It was first reported in 1993 (3). Infantile rhabdomyofibrosarcoma exhibits a few round rhabdomyoblastic cells with abundant cytoplasmic eosinophilia that are scattered within a uniform proliferation of spindle-shaped cells in a fasciculated pattern. By contrast, infantile fibrosarcoma has uniform, solidly-packed spindle cells arranged in a fascicular or herringbone pattern similar to the vascular pattern observed with hemangiopericytoma (4). Infantile rhabdomyofibrosarcoma may be identified as childhood spindle-cell sarcoma with a low degree of rhabdoid differentiation and aggressive clinical behavior (5). Overlooking the diagnosis of infantile rhabdomyofibrosarcoma may increase the chances of local recurrence or metastatic disease; therefore, aggressive multimodality treatment is required for these patients (6). Reports of rhabdomyofibrosarcoma cases are limited in the literature. The present case report describes a 26-month-old patient who presented with a slowly progressive, soft-tissue mass in the right chest wall, which was successfully resected.

Case report

A 26-month-old female was admitted to the Department of Plastic and Reconstructive Surgery at The Children's Hospital of Zhejiang University School of Medicine (Hangzhou, China) in October 2012 for the management of a large neoplasm in the right chest wall. The patient had been born at 38 weeks, weighing 3 kg, following an uncomplicated pregnancy and delivery. The lesion had been present since birth and was ~35×80 mm in size. Over the previous 2 years, the mass had been painless and had slowly increased in size until 1 month prior to admission. No audible bruit, fluctuation or thrill was present, and the skin was normal on examination. Further physical examination was unremarkable, with the exception of a 6-cm soft-tissue mass present in the right chest wall. Laboratory analysis indicated the following results: White blood cell count, 6.96×109 cells/l (normal range, 4.0–12×109 cells/l); hemoglobin count, 113 g/l (normal range, 110–140 g/l); platelet count, 256×109 cells/l (normal range, 100–400×109 cells/l); and fibrinogen level, 2.15 g/l (normal range, 1–5 g/l). Doppler ultrasound (iU Elite; Philips Healthcare, Amsterdam, The Netherlands) identified fluid collection in the subcutaneous tissue and muscle planes of the right chest wall. The tumor was initially suspected to be a lymphatic hemangioma. A posterior-anterior view of the chest was obtained using X-ray, which demonstrated that each lung field was expanded. There was no evidence of a lung mass or infiltrate, and the bilateral apices, bilateral pleural spaces and cardiac contour were all normal. The mediastinum and bilateral hila were also normal. A semicircle shadow with uniform density was observed to be protruding outwards from the soft tissue of the right chest wall. The lesion was ~33×77 mm in size, and no marked sorption or destruction of the ribs were detected (Fig. 1). The patient underwent a wide, local excision of the tumor, but did not undergo any chemotherapy following the surgical procedure. The surgical specimen was fixed with 10% neutral formaldehyde for >24 hour and paraffin embeded. The tissue slices (thickness, 4 µm) were stained with hematoxylin and eosin. Histopathology of the resected tumor identified that the spindle cells were arranged in fascicles with a herringbone pattern, and exhibited pale, eosinophilic cytoplasm and mitoses. A few round rhabdomyoblastic cells with abundant cytoplasmic eosinophilia that were scattered amoung uniform spindle-shaped cells, which were in a fasciculated pattern. (Fig. 2). However, no marked cross striation was observed in the rhabdomyoblastic cells. Immunohistochemical staining demonstrated strong positivity for vimentin, smooth muscle actin and desmin, and negativity for myogenin D1, S-100 and cluster of differentiation 34. According to the histopathological and immunohistochemical evidence the tumor was diagnosed as infantile rhabdomyofibrosarcoma. A computed tomography scan (SOMATOM Emotion 16; Siemens Healthcare, Erlangen, Germany) performed post-surgery did not reveal any signs of recurrence. Despite the aggressive nature of the lesion, there has been no evidence of recurrence or metastasis after 2 years of follow-up. Currently, the patient is alive and well. Written informed consent was obtained from the family of the patient for the publication of the present study.

Discussion

Infantile rhabdomyofibrosarcoma occupies an intermediate position between infantile fibrosarcoma and rhabdomyosarcoma in its clinical presentation, behavior morphology, immunohistochemical characteristics and ultrastructural features. Lundgren et al (3) described the first three cases of infantile rhabdomyofibrosarcoma, which were initially diagnosed as infantile fibrosarcoma. Two of the three patients with metastatic spread succumbed to the disease within 2 years of the primary operation, whereas the third patient is currently alive with a local recurrence. The three tumors deviated from infantile fibrosarcoma due to their clinical, ultrastructural, immunocytochemical and cytogenetic characteristics. An extensive comparative study was performed on these cases along with other cases of infantile fibrosarcoma (3).

Chaudhary et al (6) reviewed the limited number of infantile rhabdomyofibrosarcoma cases that were available in the literature. The median age of patients was 24 months (range, 13–48 months), with a male to female ratio of 5:2 with no specific predilection (6). In the study by Chaudhary et al, the cells were immunohistochemically positive for vimentin, smooth muscle actin and desmin, and negative for myoblobin. The present case demonstrated similarities with these previously reported studies, with the exception of the type of treatment undertaken. Myogenin has been reported to be highly specific and considered the most reliable marker for myogenesis, and Kumar et al (7) has hypothesized that myogenin is 100% specific for rhabdomyosarcoma. In addition, myogenin D1 is positive in the majority of rhabdomyoblastic cells and certain spindle cells (5). By contrast, myogenin and myogenin D1 are not expressed in infantile fibrosarcoma (8). Therefore, if a spindle-cell lesion has a high degree of muscle differentiation cross-striations and nuclear staining for myogenin, the tumor would best diagnosed and classified as infantile rhabdomyofibrosarcoma.

Generally, aggressive multimodality treatment, including surgery and adjuvant chemotherapy, is required for the treatment of rhabdomyofibrosarcoma. However, in the present case, the patient was successfully treated with wide local excision alone, and presented no signs of recurrence after 2 years of follow-up. Although the patient was recommended to undergo adjuvant chemotherapy, her parents initially refused, but eventually agreed to chemotherapy with follow-up. Another case of infantile rhabdomyofibrosarcoma was treated at The Children's Hospital of Zhejiang University School of Medicine, in which an 8-month-old male patient presented with a tumor in the back. The patient underwent surgery with no follow-up chemotherapy. However, the neoplasm recurred at the same site 3 months later. In consequence, the patient underwent a second surgery, with immunohistochemical examination of the mass displaying similar features to the first tumor. The patient underwent one cycle of chemotherapy, which consisted of an intravenous drip of vindesine (3 mg/m2) and ifosfamide (1300 mg/m2) on the 1st day, then etoposide (100 mg/m2) on days 1–3. The patient was followed-up for 3 years and had a good response to treatment (9).

In the present case, early and aggressive local surgery to remove the tumor, in addition to multidisciplinary cooperation, were successful in treating the disease. Close follow-up is highly recommended for a good prognosis in cases of infantile rhabdomyofibrosarcoma. Since the number of cases of infantile rhabdomyofibrosarcoma is extremely limited, additional accumulation of case data and extensive comparative analysis are required.

Acknowledgements

The authors would like to thank Mr. John Evans for reviewing the original manuscript (Zhejiang Ivy International High School, Hangzhou, China).

References

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Spandidos Publications style
Pan T, Chen K, Jiang RS and Zhao ZY: Misdiagnosed infantile rhabdomyofibrosarcoma: A case report. Oncol Lett 12: 2766-2768, 2016
APA
Pan, T., Chen, K., Jiang, R., & Zhao, Z. (2016). Misdiagnosed infantile rhabdomyofibrosarcoma: A case report. Oncology Letters, 12, 2766-2768. https://doi.org/10.3892/ol.2016.5032
MLA
Pan, T., Chen, K., Jiang, R., Zhao, Z."Misdiagnosed infantile rhabdomyofibrosarcoma: A case report". Oncology Letters 12.4 (2016): 2766-2768.
Chicago
Pan, T., Chen, K., Jiang, R., Zhao, Z."Misdiagnosed infantile rhabdomyofibrosarcoma: A case report". Oncology Letters 12, no. 4 (2016): 2766-2768. https://doi.org/10.3892/ol.2016.5032