1
|
Bosetti C, Bertuccio P, Negri E, La
Vecchia C, Zeegers MP and Boffetta P: Pancreatic cancer: Overview
of descriptive epidemiology. Mol Carcinog. 51:3–13. 2012.
View Article : Google Scholar : PubMed/NCBI
|
2
|
Guo J, Gao J, Li Z, Gong Y, Man X, Jin J
and Wu H: Adenovirus vector-mediated Gli1 siRNA induces growth
inhibition and apoptosis in human pancreatic cancer with
Smo-dependent or Smo-independent Hh pathway activation in vitro and
in vivo. Cancer Lett. 339:185–194. 2013. View Article : Google Scholar : PubMed/NCBI
|
3
|
Hao K, Tian XD, Qin CF, Xie XH and Yang
YM: Hedgehog signaling pathway regulates human pancreatic cancer
cell proliferation and metastasis. Oncol Rep. 29:1124–1132.
2013.PubMed/NCBI
|
4
|
Morton JP, Mongeau ME, Klimstra DS, Morris
JP, Lee YC, Kawaguchi Y, Wright CV, Hebrok M and Lewis BC: Sonic
hedgehog acts at multiple stages during pancreatic tumorigenesis.
Proc Natl Acad Sci USA. 104:5103–5108. 2007. View Article : Google Scholar : PubMed/NCBI
|
5
|
Kelleher FC: Hedgehog signaling and
therapeutics in pancreatic cancer. Carcinogenesis. 32:445–451.
2011. View Article : Google Scholar : PubMed/NCBI
|
6
|
Ingham PW and McMahon AP: Hedgehog
signaling in animal development: Paradigms and principles. Genes
Dev. 15:3059–3087. 2001. View Article : Google Scholar : PubMed/NCBI
|
7
|
Stone DM, Hynes M, Armanini M, Swanson TA,
Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, et
al: The tumour-suppressor gene patched encodes a candidate receptor
for Sonic hedgehog. Nature. 384:129–134. 1996. View Article : Google Scholar : PubMed/NCBI
|
8
|
Akiyama H, Shigeno C, Hiraki Y, Shukunami
C, Kohno H, Akagi M, Konishi J and Nakamura T: Cloning of a mouse
smoothened cDNA and expression patterns of hedgehog signalling
molecules during chondrogenesis and cartilage differentiation in
clonal mouse EC cells, ATDC5. Biochem Biophys Res Commun.
235:142–147. 1997. View Article : Google Scholar : PubMed/NCBI
|
9
|
Kasper M, Regl G, Frischauf AM and Aberger
F: GLI transcription factors: Mediators of oncogenic hedgehog
signaling. Eur J Cancer. 42:437–445. 2006. View Article : Google Scholar : PubMed/NCBI
|
10
|
Ailles L and Siu LL: Targeting the
Hedgehog pathway in cancer: Can the spines be smoothened? Clin
Cancer Res. 17:2071–2073. 2011. View Article : Google Scholar : PubMed/NCBI
|
11
|
Tang JY and Marghoob AA: Emerging
treatments and signaling pathway inhibitors. Semin Cutan Med Surg.
30(Suppl 4): S14–S18. 2011. View Article : Google Scholar : PubMed/NCBI
|
12
|
Schnidar H, Eberl M, Klingler S,
Mangelberger D, Kasper M, Hauser-Kronberger C, Regl G, Kroismayr R,
Moriggl R, Sibilia M and Aberger F: Epidermal growth factor
receptor signaling synergizes with hedgehog/GLI in oncogenic
transformation via activation of the MEK/ERK/JUN pathway. Cancer
Res. 69:1284–1292. 2009. View Article : Google Scholar : PubMed/NCBI
|
13
|
LoRusso PM, Rudin CM, Reddy JC, Tibes R,
Weiss GJ, Borad MJ, Hann CL, Brahmer JR, Chang I, Darbonne WC, et
al: Phase I trial of hedgehog pathway inhibitor vismodegib
(GDC-0449) in patients with refractory, locally advanced or
metastatic solid tumors. Clin Cancer Res. 17:2502–2511. 2011.
View Article : Google Scholar : PubMed/NCBI
|
14
|
Mazumdar T, Devecchio J, Agyeman A, Shi T
and Houghton JA: Blocking Hedgehog survival signaling at the level
of the GLI genes induces DNA damage and extensive cell death in
human colon carcinoma cells. Cancer Res. 71:5904–5914. 2011.
View Article : Google Scholar : PubMed/NCBI
|
15
|
Kimura H, Stephen D, Joyner A and Curran
T: Gli1 is important for medulloblastoma formation in Ptc1+/- mice.
Oncogene. 24:4026–4036. 2005. View Article : Google Scholar : PubMed/NCBI
|
16
|
Thiyagarajan S, Bhatia N, Reagan-Shaw S,
Cozma D, Thomas-Tikhonenko A, Ahmad N and Spiegelman VS: Role of
GLI2 transcription factor in growth and tumorigenicity of prostate
cells. Cancer Res. 67:10642–10646. 2007. View Article : Google Scholar : PubMed/NCBI
|
17
|
Lauth M, Bergström A, Shimokawa T and
Toftgård R: Inhibition of GLI-mediated transcription and tumor cell
growth by small-molecule antagonists. Proc Natl Acad Sci USA.
104:8455–8460. 2007. View Article : Google Scholar : PubMed/NCBI
|
18
|
Zahreddine HA, Culjkovic-Kraljacic B,
Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB,
Cerchietti L, Cocolakis E, et al: The sonic hedgehog factor GLI1
imparts drug resistance through inducible glucuronidation. Nature.
511:90–93. 2014. View Article : Google Scholar : PubMed/NCBI
|
19
|
Li H, Kim JY, Hyeon J, Lee HJ and Ryu JH:
In vitro antiinflammatory activity of a new sesquiterpene lactone
isolated from Siegesbeckia glabrescens. Phytother Res.
25:1323–1327. 2011.PubMed/NCBI
|
20
|
Cho YR, Choi SW and Seo DW: The in vitro
antitumor activity of Siegesbekia glabrescens against ovarian
cancer through suppression of receptor tyrosine kinase expression
and the signaling pathways. Oncol Rep. 30:221–226. 2013.PubMed/NCBI
|
21
|
Chen JK, Taipale J, Young KE, Maiti T and
Beachy PA: Small molecule modulation of Smoothened activity. Proc
Natl Acad Sci USA. 99:14071–14076. 2002. View Article : Google Scholar : PubMed/NCBI
|
22
|
Nakamura TT, Aikawa M, Iwamoto-Enomoto M,
Iwamoto M, Higuchi Y, Pacifici M, Kinto N, Yamaguchi A, Noji S,
Kurisu K and Matsuya T: Induction of osteogenic differentiation by
hedgehog proteins. Biochem Biophys Res Commun. 237:465–469. 1997.
View Article : Google Scholar : PubMed/NCBI
|
23
|
Lee ST, Welch KD, Panter KE, Gardner DR,
Garrossian M and Chang CW: Cyclopamine: From cyclops lambs to
cancer treatment. J Agric Food Chem. 62:7355–7362. 2014. View Article : Google Scholar : PubMed/NCBI
|
24
|
Stanton BZ and Peng LF: Small-molecule
modulators of the Sonic hedgehog signaling pathway. Mol Biosyst.
6:44–54. 2009. View
Article : Google Scholar : PubMed/NCBI
|
25
|
Riobó NA, Lu K, Ai X, Haines GM and
Emerson CP Jr: Phosphoinositide 3-kinase and akt are essential for
Sonic hedgehog signaling. Proc Natl Acad Sci USA. 103:4505–4510.
2006. View Article : Google Scholar : PubMed/NCBI
|
26
|
Lauth M and Toftgård R: Hedgehog signaling
and pancreatic tumor development. Adv Cancer Res. 110:1–17. 2011.
View Article : Google Scholar : PubMed/NCBI
|
27
|
Xie J, Bartels CM, Barton SW and Gu D:
Targeting hedgehog signaling in cancer: Research and clinical
developments. Onco Targets Ther. 6:1425–1435. 2013. View Article : Google Scholar : PubMed/NCBI
|
28
|
Park HL, Bai C, Platt KA, Matise MP,
Beeghly A, Hui CC, Nakashima M and Joyner AL: Mouse Gli1 mutants
are viable but have defects in SHH signaling in combination with a
Gli2 mutation. Development. 127:1593–1605. 2000.PubMed/NCBI
|
29
|
Katoh Y and Katoh M: Hedgehog signaling
pathway and gastrointestinal stem cell signaling network (review).
Int J Mol Med. 18:1019–1023. 2006.PubMed/NCBI
|
30
|
Hu MC, Mo R, Bhella S, Wilson CW, Chuang
PT, Hui CC and Rosenblum ND: GLI3-dependent transcriptional
repression of Gli1, Gli2 and kidney patterning genes disrupts renal
morphogenesis. Development. 133:569–578. 2006. View Article : Google Scholar : PubMed/NCBI
|
31
|
Bai CB and Joyner AL: Gli1 can rescue the
in vivo function of Gli2. Development. 128:5161–5172.
2001.PubMed/NCBI
|
32
|
Di Magno L, Coni S, Di Marcotullio L and
Canettieri G: Digging a hole under Hedgehog: Downstream inhibition
as an emerging anticancer strategy. Biochim Biophys Acta.
1856:62–72. 2015.PubMed/NCBI
|
33
|
Reifenberger J, Wolter M, Knobbe CB,
Köhler B, Schönicke A, Scharwächter C, Kumar K, Blaschke B, Ruzicka
T and Reifenberger G: Somatic mutations in the PTCH, SMOH, SUFUH
and TP53 genes in sporadic basal cell carcinomas. Br J Dermatol.
152:43–51. 2005. View Article : Google Scholar : PubMed/NCBI
|
34
|
Bahra M, Kamphues C, Boas-Knoop S, Lippert
S, Esendik U, Schüller U, Hartmann W, Waha A, Neuhaus P, Heppner F,
et al: Combination of hedgehog signaling blockage and chemotherapy
leads to tumor reduction in pancreatic adenocarcinomas. Pancreas.
41:222–229. 2012. View Article : Google Scholar : PubMed/NCBI
|
35
|
Wang XD, Inzunza H, Chang H, Qi Z, Hu B,
Malone D and Cogswell J: Mutations in the hedgehog pathway genes
SMO and PTCH1 in human gastric tumors. PLoS One. 8:e544152013.
View Article : Google Scholar : PubMed/NCBI
|
36
|
Bisht S, Brossart P, Maitra A and Feldmann
G: Agents targeting the hedgehog pathway for pancreatic cancer
treatment. Curr Opin Investig Drugs. 11:1387–1398. 2010.PubMed/NCBI
|
37
|
Lauth M and Toftgård R: Non-canonical
activation of GLI transcription factors: Implications for targeted
anti-cancertherapy. Cell Cycle. 6:2458–2463. 2007. View Article : Google Scholar : PubMed/NCBI
|
38
|
Lee Y, Kawagoe R, Sasai K, Li Y, Russell
HR, Curran T and McKinnon PJ: Loss of suppressor-of-fused function
promotes tumorigenesis. Oncogene. 26:6442–6447. 2007. View Article : Google Scholar : PubMed/NCBI
|
39
|
Kim WK, Meliton V, Bourquard N, Hahn TJ
and Parhami F: Hedgehog signaling and osteogenic differentiation in
multipotent bone marrow stromal cells are inhibited by oxidative
stress. J Cell Biochem. 111:1199–1209. 2010. View Article : Google Scholar : PubMed/NCBI
|
40
|
Fendrich V, Oh E, Bang S, Karikari C,
Ottenhof N, Bisht S, Lauth M, Brossart P, Katsanis N, Maitra A and
Feldmann G: Ectopic overexpression of Sonic Hedgehog (Shh) induces
stromal expansion and metaplasia in the adult murine pancreas.
Neoplasia. 13:923–930. 2011. View Article : Google Scholar : PubMed/NCBI
|
41
|
Bahra M, Kamphues C, Boas-Knoop S, Lippert
S, Esendik U, Schüller U, Hartmann W, Waha A, Neuhaus P, Heppner F,
et al: Combination of hedgehog signaling blockage and chemotherapy
leads to tumor reduction in pancreatic adenocarcinomas. Pancreas.
41:222–229. 2012. View Article : Google Scholar : PubMed/NCBI
|
42
|
Thayer SP, di Magliano MP, Heiser PW,
Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernández-del
Castillo C, Yajnik V, et al: Hedgehog is an early and late mediator
of pancreatic cancer tumorigenesis. Nature. 425:851–856. 2003.
View Article : Google Scholar : PubMed/NCBI
|
43
|
Hu WG, Liu T, Xiong JX and Wang CY:
Blockade of sonic hedgehog signal pathway enhances
antiproliferative effect of EGFR inhibitor in pancreatic cancer
cells. Acta Pharmacol Sin. 28:1224–1230. 2007. View Article : Google Scholar : PubMed/NCBI
|
44
|
Hosoya T, Arai MA, Koyano T, Kowithayakorn
T and Ishibashi M: Naturally occurring small-molecule inhibitors of
hedgehog/GLI-mediated transcription. Chembiochem. 9:1082–1092.
2008. View Article : Google Scholar : PubMed/NCBI
|
45
|
Hyman JM, Firestone AJ, Heine VM, Zhao Y,
Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, et al:
Small-molecule inhibitors reveal multiple strategies for hedgehog
pathway blockade. Proc Natl Acad Sci USA. 106:14132–14137. 2009.
View Article : Google Scholar : PubMed/NCBI
|
46
|
Katoh Y and Katoh M: Hedgehog target
genes: Mechanisms of carcinogenesis induced by aberrant hedgehog
signaling activation. Curr Mol Med. 9:873–886. 2009. View Article : Google Scholar : PubMed/NCBI
|
47
|
Xu X, Su B, Xie C, Wei S, Zhou Y, Liu H,
Dai W, Cheng P, Wang F, Xu X and Guo C: Sonic hedgehog-Gli1
signaling pathway regulates the epithelial mesenchymal transition
(EMT) by mediating a new target gene, S100A4, in pancreatic cancer
cells. PLoS One. 9:e96442014.
|
48
|
Gill PS and Rosenblum ND: Control of
murine kidney development by sonic hedgehog and its GLI effectors.
Cell Cycle. 5:1426–1430. 2006. View Article : Google Scholar : PubMed/NCBI
|
49
|
Onishi H and Katano M: Hedgehog signaling
pathway as a new therapeutic target in pancreatic cancer. World J
Gastroenterol. 20:2335–2342. 2014. View Article : Google Scholar : PubMed/NCBI
|