Ameloblastic carcinoma of the maxilla: A case report and an updated review of the literature

Moro,Alessandro; Foresta,Enrico; Gasparini,Giulio; Pelo,Sandro; Forcione,Mario; Cristallini,Enrico  Giuseppe; Toraldo,Marco; Lorenzo,Cardarelli; Falchi,Marco; Saponaro,Gianmarco

doi:10.3892/ol.2016.5272

Ameloblastic carcinoma of the maxilla: A case report and an updated review of the literature

Authors:
- Alessandro Moro
- Enrico Foresta
- Giulio Gasparini
- Sandro Pelo
- Mario Forcione
- Enrico Giuseppe Cristallini
- Marco Toraldo
- Cardarelli Lorenzo
- Marco Falchi
- Gianmarco Saponaro
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Affiliations: Maxillofacial Surgery Unit, Faculty of Medicine, University Hospital ‘A. Gemelli’, Catholic University of the Sacred Heart, I‑00168 Rome, Italy, Pathological Anatomy Service, Foligno Hospital, I‑06034 Foligno, Italy, Private Practitioner, I‑06034 Foligno, Italy, Department of Maxillofacial Surgery, Foligno Hospital, I‑06034 Foligno, Italy
Published online on: October 17, 2016 https://doi.org/10.3892/ol.2016.5272
Pages: 4339-4350
Copyright: © Moro et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ameloblastic carcinoma (AC) is an uncommon malignant odontogenic tumor that can be difficult to differentiate from ameloblastoma and can arise directly as an undifferentiated lesion or from a pre‑existing benign lesion. The current study presents a novel case of primary maxillary AC and review the literature on AC of the maxilla. The review of the literature indicates that secondary tumors and posterior localization are associated with a higher tendency for recurrence and, often, multiple recurrences. Surgical therapy, eventually followed by radiotherapy, is the treatment modality most frequently applied, while the role of chemotherapy remains unclear. Several new cases of maxillary AC have been recently described in literature, making this pathology more frequent than previously considered; this is perhaps an indication of an increased diagnostic sensibility, rather than a real increase in the incidence of the disease itself.

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