Prognostic significance of AKR1B10 gene expression in hepatocellular carcinoma and surrounding non-tumorous liver tissue

  • Authors:
    • Fuminori Sonohara
    • Yoshikuni Inokawa
    • Mitsuhiro Hishida
    • Mitsuro Kanda
    • Yoko Nishikawa
    • Suguru Yamada
    • Tsutomu Fujii
    • Hiroyuki Sugimoto
    • Yasuhiro Kodera
    • Shuji Nomoto
  • View Affiliations

  • Published online on: October 11, 2016     https://doi.org/10.3892/ol.2016.5240
  • Pages: 4821-4828
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Abstract

When assessing outcome in hepatocellular carcinoma (HCC), it is important to consider prognostic factors in background non-tumorous liver tissue as well as in the tumor, since multiple occurrence is associated with background liver status such as hepatitis. The current study aimed to elucidate molecular prognostic predictors that have an association with HCC background non‑tumorous tissue. Microarray expression profiling identified aldo‑keto reductase family 1, member B10 (AKR1B10) as a putative non‑tumorous prognostic factor, and AKR1B10 gene expression was investigated in 158 curatively resected HCC cases by reverse transcription‑quantitative polymerase chain reaction. AKR1B10 expression (AKR1B10 value/GAPDH value x 1,000) was significantly higher in tumor tissue (median, 9.2200; range, 0.0003‑611.0200; n=158) than in the corresponding non‑tumorous tissue (median, 0.5461; range, 0.0018‑69.0300; n=158) (P<0.001). When the samples were grouped according to AKR1B10 expression in tumor tissue relative to non‑tumorous tissue, tumor
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Sonohara F, Inokawa Y, Hishida M, Kanda M, Nishikawa Y, Yamada S, Fujii T, Sugimoto H, Kodera Y, Nomoto S, Nomoto S, et al: Prognostic significance of AKR1B10 gene expression in hepatocellular carcinoma and surrounding non-tumorous liver tissue. Oncol Lett 12: 4821-4828, 2016
APA
Sonohara, F., Inokawa, Y., Hishida, M., Kanda, M., Nishikawa, Y., Yamada, S. ... Nomoto, S. (2016). Prognostic significance of AKR1B10 gene expression in hepatocellular carcinoma and surrounding non-tumorous liver tissue. Oncology Letters, 12, 4821-4828. https://doi.org/10.3892/ol.2016.5240
MLA
Sonohara, F., Inokawa, Y., Hishida, M., Kanda, M., Nishikawa, Y., Yamada, S., Fujii, T., Sugimoto, H., Kodera, Y., Nomoto, S."Prognostic significance of AKR1B10 gene expression in hepatocellular carcinoma and surrounding non-tumorous liver tissue". Oncology Letters 12.6 (2016): 4821-4828.
Chicago
Sonohara, F., Inokawa, Y., Hishida, M., Kanda, M., Nishikawa, Y., Yamada, S., Fujii, T., Sugimoto, H., Kodera, Y., Nomoto, S."Prognostic significance of AKR1B10 gene expression in hepatocellular carcinoma and surrounding non-tumorous liver tissue". Oncology Letters 12, no. 6 (2016): 4821-4828. https://doi.org/10.3892/ol.2016.5240