Open Access

Decreased expression of speckle‑type POZ protein for the prediction of poor prognosis in patients with non‑small cell lung cancer

  • Authors:
    • Jing‑Jing Li
    • Jian‑Feng Zhang
    • Su‑Mei Yao
    • Hua Huang
    • Shu Zhang
    • Minxing Zhao
    • Jian‑An Huang
  • View Affiliations

  • Published online on: July 10, 2017     https://doi.org/10.3892/ol.2017.6567
  • Pages: 2743-2748
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Speckle‑type POZ domain protein (SPOP) has been acknowledged as a tumor suppressor gene in numerous types of cancer. However, SPOP expression and its prognostic role in human non‑small cell lung cancer (NSCLC) remain unknown. The present study investigated SPOP expression in NSCLC and evaluated its prognostic significance in patients with NSCLC. The results demonstrated that SPOP expression was significantly downregulated in NSCLC tissues at the mRNA and protein level compared with normal lung tissues using reverse transcription‑quantitative polymerase chain reaction, and western blot analysis. Immunohistochemical staining results also demonstrated that SPOP was expressed at a low level in 84.1% (132/157) of NSCLC samples and at a high level in 52.2% (12/23) of normal lung samples, whereby the difference was statistically significant (P<0.001). In addition, it was revealed that the level of SPOP was associated with histologic type (P=0.003), tumor differentiation (P=0.046), tumor size (P=0.0036), lymph node metastasis (P=0.041) and clinical stages (P=0.046). Furthermore, the overall survival of patients with high SPOP expression was significantly increased compared with that of patients with low SPOP expression (P=0.003). These results revealed that SPOP expression was downregulated in NSCLC tissues and associated with poor prognosis in patients with NSCLC, suggesting that SPOP is an independent prognostic marker candidate for NSCLC.
View Figures
View References

Related Articles

Journal Cover

September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li JJ, Zhang JF, Yao SM, Huang H, Zhang S, Zhao M and Huang JA: Decreased expression of speckle‑type POZ protein for the prediction of poor prognosis in patients with non‑small cell lung cancer. Oncol Lett 14: 2743-2748, 2017.
APA
Li, J., Zhang, J., Yao, S., Huang, H., Zhang, S., Zhao, M., & Huang, J. (2017). Decreased expression of speckle‑type POZ protein for the prediction of poor prognosis in patients with non‑small cell lung cancer. Oncology Letters, 14, 2743-2748. https://doi.org/10.3892/ol.2017.6567
MLA
Li, J., Zhang, J., Yao, S., Huang, H., Zhang, S., Zhao, M., Huang, J."Decreased expression of speckle‑type POZ protein for the prediction of poor prognosis in patients with non‑small cell lung cancer". Oncology Letters 14.3 (2017): 2743-2748.
Chicago
Li, J., Zhang, J., Yao, S., Huang, H., Zhang, S., Zhao, M., Huang, J."Decreased expression of speckle‑type POZ protein for the prediction of poor prognosis in patients with non‑small cell lung cancer". Oncology Letters 14, no. 3 (2017): 2743-2748. https://doi.org/10.3892/ol.2017.6567