Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis

  • Authors:
    • Chunwa Jiang
    • Juanjing Wang
    • Chen Dong
    • Wei Wei
    • Jiang Li
    • Xiaomeng Li
  • View Affiliations

  • Published online on: July 7, 2017     https://doi.org/10.3892/ol.2017.6536
  • Pages: 3096-3102
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Abstract

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes, which perform a crucial role in the metastatic spread of cancer. MMP2 and MMP9 are important cancer‑associated MMPs in the invasion and metastasis of the majority of carcinomas. As a new member of the membrane‑type MMPs, the function of MMP16 associated with invasion and metastasis of cancer remains unclear. In the present study, MMP16 expression in prostate cancer (PCa) tissues and cells was examined, and the high expression of MMP16 was revealed to be associated with advanced prostate tumor stage and PCa cell metastasis. The membrane localization of MMP16 is required for its function. To the best of our knowledge, the present study is the first to demonstrate that MMP16 is associated with advanced prostate tumor stage. As an important mediator of PCa cell metastasis, the membrane localization of MMP16 is required, and MMP16 may be an ideal target candidate for preventing PCa cell metastasis.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jiang C, Wang J, Dong C, Wei W, Li J and Li X: Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis. Oncol Lett 14: 3096-3102, 2017
APA
Jiang, C., Wang, J., Dong, C., Wei, W., Li, J., & Li, X. (2017). Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis. Oncology Letters, 14, 3096-3102. https://doi.org/10.3892/ol.2017.6536
MLA
Jiang, C., Wang, J., Dong, C., Wei, W., Li, J., Li, X."Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis". Oncology Letters 14.3 (2017): 3096-3102.
Chicago
Jiang, C., Wang, J., Dong, C., Wei, W., Li, J., Li, X."Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis". Oncology Letters 14, no. 3 (2017): 3096-3102. https://doi.org/10.3892/ol.2017.6536