Difference in expression of two neurokinin‑1 receptors in adenoma and carcinoma from patients that underwent radical surgery for colorectal carcinoma

  • Authors:
    • Xia Gao
    • Zhenjun Wang
  • View Affiliations

  • Published online on: July 15, 2017     https://doi.org/10.3892/ol.2017.6588
  • Pages: 3729-3733
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Abstract

Mechanisms underlying tumor progression remain a main problem in the diagnosis and treatment of patients with tumors. The present study compared the expression of full‑length neurokinin‑1 receptors (fl‑NK‑1R) and truncated neurokinin‑1 receptors (tr‑NK‑1R) in adenoma and carcinoma from patients with colorectal carcinoma, to explore their possible contributions in adenoma‑carcinoma progression. Samples were collected immediately following colorectal carcinoma surgery. Using reverse transcription‑quantitative polymerase chain reaction and immunohistochemical staining, the relative mRNA and protein levels of tr‑NK‑1R and fl‑NK‑1R were compared in adenoma and carcinoma. tr‑NK‑1R mRNA was significantly upregulated (1.7 fold; P=0.026) in carcinoma tissues compared with adenoma tissues, while the fl‑NK‑1R transcription level showed no difference (P=0.438). No significant change was observed in the fl‑NK‑1R protein level in adenoma, carcinoma and peri‑carcinoma tissues (P=0.244). However, total neurokinin‑1 receptor (NK‑1R) protein levels in adenoma and carcinoma tissues were significantly increased compared to peri‑carcinoma tissue (P=0.026 and P=0.007, respectively). The outcomes suggested that the increase in total NK‑1R protein in adenoma and carcinoma tissues is the result of the increase in tr‑NK‑1R levels. The present findings indicate that tr‑NK‑1R serves an important role in colorectal adenoma progression, with a possible role in adenoma‑carcinoma progression. Thus, tr‑NK‑1R may be used as a marker for diagnosing and treating patients with colorectal adenomas.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Gao X and Wang Z: Difference in expression of two neurokinin‑1 receptors in adenoma and carcinoma from patients that underwent radical surgery for colorectal carcinoma. Oncol Lett 14: 3729-3733, 2017.
APA
Gao, X., & Wang, Z. (2017). Difference in expression of two neurokinin‑1 receptors in adenoma and carcinoma from patients that underwent radical surgery for colorectal carcinoma. Oncology Letters, 14, 3729-3733. https://doi.org/10.3892/ol.2017.6588
MLA
Gao, X., Wang, Z."Difference in expression of two neurokinin‑1 receptors in adenoma and carcinoma from patients that underwent radical surgery for colorectal carcinoma". Oncology Letters 14.3 (2017): 3729-3733.
Chicago
Gao, X., Wang, Z."Difference in expression of two neurokinin‑1 receptors in adenoma and carcinoma from patients that underwent radical surgery for colorectal carcinoma". Oncology Letters 14, no. 3 (2017): 3729-3733. https://doi.org/10.3892/ol.2017.6588