MicroRNA‑497 inhibits tumor growth through targeting insulin receptor substrate 1 in colorectal cancer
- Yanjie Xu
- Jianping Chen
- Cao Gao
- Danxia Zhu
- Xiaoli Xu
- Changping Wu
- Jingting Jiang
Published online on: September 22, 2017
Copyright: © Xu et al.
This is an open access article distributed under the terms of Creative Commons Attribution License.
MicroRNAs (miRNAs) have been demonstrated to serve an important role in diverse biological processes and cancer progression. Downregulation of microRNA‑497 (miR‑497) has been observed in human colorectal cancer (CRC) tissues, but the function of miR‑497 in CRC has not been well investigated. In the present study, it was demonstrated that expression of miR‑497 was significantly downregulated in human CRC tissues compared to adjacent normal tissues. Enforced expression of miR‑497 inhibited proliferation, migration and invasion abilities of CRC cell lines SW1116 and SW480. Furthermore, overexpression of miR‑497 inhibited phosphoinositide 3‑kinase/AKT and mitogen‑activated protein kinase/extracellular signal‑regulated kinase signaling by targeting insulin receptor substrate 1 (IRS1). In human clinical specimens, IRS1 was inversely correlated with miR‑497 in CRC tissues. Collectively, the results of the present study demonstrate that miR‑497 is a tumor suppressor miRNA and indicate its potential application for the treatment of human CRC in the future.