Open Access

Identification of molecular mechanisms of glutamine in pancreatic cancer

  • Authors:
    • Zhen‑Yi Jia
    • Tong‑Yi Shen
    • Wei Jiang
    • Huan‑Long Qin
  • View Affiliations

  • Published online on: September 26, 2017     https://doi.org/10.3892/ol.2017.7068
  • Pages:6395-6402
  • Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to explore the critical genes and molecular mechanisms in pancreatic cancer (PC) cells with glutamine. By analyzing microarray data GSE17632 from the Gene Expression Omnibus database, the DEGs between PC cells treated with glutamine and without glutamine were evaluated. Additionally, function enrichment analyses and protein‑protein interaction (PPI) network construction of DEGs were performed. Network module and literature mining analyses were performed to analyze the critical DEGs in PC cells. In total, 495 genes were selected as DEGs between control and glutamine cells in PC. These DEGs were mainly enriched in several Gene Ontology (GO) terms in biological process, cellular components and molecular function. Additionally, they were also enriched in certain pathways, including metabolic pathways and the Janus kinase‑signal transducer and activator of transcription (JAK‑STAT) signaling pathway. MYC, heat shock 70kDa protein 5 (HSPA5), interleukin 8 (IL8), and chemokine (C‑X‑C motif) receptor 4 (CXCR4) were hub genes in the PPI network. Furthermore, two sub‑network modules of PPI network and two co‑occurrence networks were obtained. The DEGs of MYC, HSPA5, IL18 and CXCR4 may exert important roles in molecular mechanisms of PC cells with glutamine.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Jia, Z., Shen, T., Jiang, W., & Qin, H. (2017). Identification of molecular mechanisms of glutamine in pancreatic cancer. Oncology Letters, 14, 6395-6402. https://doi.org/10.3892/ol.2017.7068
MLA
Jia, Z., Shen, T., Jiang, W., Qin, H."Identification of molecular mechanisms of glutamine in pancreatic cancer". Oncology Letters 14.6 (2017): 6395-6402.
Chicago
Jia, Z., Shen, T., Jiang, W., Qin, H."Identification of molecular mechanisms of glutamine in pancreatic cancer". Oncology Letters 14, no. 6 (2017): 6395-6402. https://doi.org/10.3892/ol.2017.7068