Open Access

HNF‑4α promotes multidrug resistance of gastric cancer cells through the modulation of cell apoptosis

  • Authors:
    • Yubo Ma
    • Xufu Wei
    • Zhongjun Wu
  • View Affiliations

  • Published online on: September 28, 2017     https://doi.org/10.3892/ol.2017.7095
  • Pages:6477-6484
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Multidrug resistance (MDR) typically leads to treatment failure, and is associated with disease progression of gastric cancer (GC). In the present study, a total of 15 aberrantly activated transcription factors (TFs) were detected in chemo‑resistant GC cells using a TF Activation Profiling Plate Array. Among these TFs, hepatocyte nuclear factor (HNF)‑4α was significantly upregulated in multidrug‑resistant GC cells (P=0.019). The overexpression of HNF‑4α was able to cause resistance to multiple chemotherapeutics, whereas inhibition of HNF‑4α appeared to reverse cancer cell resistance. Further studies demonstrated that HNF‑4α had no clear influence on drug transportation; however, inhibition of drug‑induced cell apoptosis occurred as B‑cell lymphoma 2 (Bcl‑2) expression increased in GC cells. Additionally, immunohistochemistry demonstrated that HNF‑4α was overexpressed in human GC tissues, and associated with tumor stage and lymph node metastasis. In conclusion, the results of the present study indicate the involvement of TFs in MDR in GC, and suggest that HNF‑4α may enhance MDR in GC by regulating cell apoptosis and Bcl‑2 expression.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Ma, Y., Wei, X., & Wu, Z. (2017). HNF‑4α promotes multidrug resistance of gastric cancer cells through the modulation of cell apoptosis. Oncology Letters, 14, 6477-6484. https://doi.org/10.3892/ol.2017.7095
MLA
Ma, Y., Wei, X., Wu, Z."HNF‑4α promotes multidrug resistance of gastric cancer cells through the modulation of cell apoptosis". Oncology Letters 14.6 (2017): 6477-6484.
Chicago
Ma, Y., Wei, X., Wu, Z."HNF‑4α promotes multidrug resistance of gastric cancer cells through the modulation of cell apoptosis". Oncology Letters 14, no. 6 (2017): 6477-6484. https://doi.org/10.3892/ol.2017.7095