Duodenal angiomyolipoma with multiple systemic vascular malformations and aneurysms: A case report and literature review

Wang,Yiqiu; Zhang,Xiuli; Liu,Peng; Jiang,Guan; Liu,Wenlou

doi:10.3892/ol.2017.7011

Duodenal angiomyolipoma with multiple systemic vascular malformations and aneurysms: A case report and literature review

Authors:
- Yiqiu Wang
- Xiuli Zhang
- Peng Liu
- Guan Jiang
- Wenlou Liu
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Affiliations: Department of Surgical Oncology, Xuzhou Central Hospital, Southeast University Cancer Institute, Xuzhou, Jiangsu 221009, P.R. China, Department of Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221006, P.R. China, Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, Hubei 430071, P.R. China
Published online on: September 21, 2017 https://doi.org/10.3892/ol.2017.7011
Pages: 6659-6663
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Angiomyolipomas (AMLs) are barely benign mesenchymal tumors that usually occur in the kidneys and may be associated with tuberous sclerosis complex (TSC). Extrarenal AMLs are markedly rare and infrequently observed in the duodenum. In the present case report, a 22‑year‑old female patient with duodenal AMLs presenting multiple systemic vascular malformations and aneurysms is described. The patient had a medical history of aneurysm rupture of the right subclavian artery and no other manifestation of TSC. Surgical intervention was performed. Following complete tumor resection, the patient declined to be treated further for vascular lesions. Pathological and immunohistochemical examination confirmed the diagnosis of duodenal AMLs. No tumor recurrence or progression of the vascular lesions was observed within 24 months of follow‑up. This case report demonstrates the scarcity of duodenal AMLs with multiple systemic vascular malformations and aneurysms, which may be associated with novel gene mutations or TSC; however, further verification by gene sequencing is required.

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