Myxoid liposarcoma with cartilaginous differentiation showing DDIT3 rearrangement

Suzuki,Kayo; Yasuda,Taketoshi; Watanabe,Kenta; Hori,Takeshi; Kanamori,Masahiko; Kimura,Tomoatsu

doi:10.3892/ol.2017.7056

Myxoid liposarcoma with cartilaginous differentiation showing DDIT3 rearrangement

Authors:
- Kayo Suzuki
- Taketoshi Yasuda
- Kenta Watanabe
- Takeshi Hori
- Masahiko Kanamori
- Tomoatsu Kimura
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Affiliations: Department of Orthopaedic Surgery, University of Toyama, Toyama, Toyama 930‑0194, Japan, Department of Orthopaedic Surgery, Iiyama Red Cross Hospital, Iiyama, Nagano 389‑2295, Japan, Department of Human Science 1, University of Toyama, Toyama, Toyama 930‑0194, Japan
Published online on: September 25, 2017 https://doi.org/10.3892/ol.2017.7056
Pages: 6789-6794

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Abstract

Myxoid liposarcoma (MLPS) is the second most common histologic subtype of liposarcoma. However, cartilaginous differentiation within MLPS is an extremely rare phenomenon, with only 7 cases of MLPS with cartilaginous differentiation reported to date. The majority of MLPS cases show the t(12;16)(q13;p11) translocation, resulting in the fused in sarcoma‑DNA damage‑inducible transcript 3 (FUS‑DDIT3) fusion gene. This fusion gene as a hallmark of MLPS is very useful for differential diagnosis from other soft tissue sarcomas, and the associated protein, FUS‑DDIT3, performs an important role in the phenotypic selection of targeted multipotent mesenchymal cells during oncogenesis. In this report, a case of MLPS with cartilaginous differentiation that occurred in the thigh of a 44‑year‑old woman is described. Histopathologically, the tumor was composed of a typical myxoid liposarcoma area and a mature hyaline cartilaginous area. Using fluorescence in situ hybridization analysis, rearrangement of the DDIT3 gene was detected in not only the liposarcomatous area but also in the chondrocytes of the cartilaginous area. Based on these findings, the cartilaginous differentiation area appears to be partially associated with oncogenesis through the specific fusion gene FUS‑DDIT3.

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1	Weiss SW and Goldblum JR: LiposarcomaEnzinger and Weiss's Soft Tissue Tumors. 5th. Weiss SW Enzinger and Goldblum JR: Mosby Inc.; St. Louis: pp. 477–516. 2008
2	Dei Tos AP and Pedeutour F: Atypical lipomatous tumorWHO Classification of Tumours of Soft Tissue and Bone. Fletcher CDM, Bridge JA, Hogendoorn PCW and Mertens F: IARC; Lyon: pp. 33–43. 2013
3	Coindre JM, Pédeutour F and Aurias A: Well-differentiated and dedifferentiated liposarcomas. Virchows Arch. 456:167–179. 2010. View Article : Google Scholar : PubMed/NCBI
4	Antonescu CR and Ladanyi M: Myxoid liposarcomaWHO Classification of Tumours of Soft Tissue and Bone. Fletcher CDM, Bridge JA, Hogendoorn PCW and Mertens F: IARC; Lyon: pp. 39–41. 2013
5	Antonescu CR, Tschernyavsky SJ, Decuseara R, Leung DH, Woodruff JM, Brennan MF, Bridge JA, Neff JR, Goldblum JR and Ladanyi M: Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: A molecular and clinicopathologic study of 82 cases. Clin Cancer Res. 7:3977–3987. 2001.PubMed/NCBI
6	Hosaka T, Nakashima Y, Kusuzaki K, Murata H, Nakayama T, Nakamata T, Aoyama T, Okamoto T, Nishijo K, Araki N, et al: A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma. J Mol Diagn. 4:164–171. 2002. View Article : Google Scholar : PubMed/NCBI
7	Idbaih A, Coindre JM, Derré J, Mariani O, Terrier P, Ranchère D, Mairal A and Aurias A: Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances. Lab Invest. 85:176–181. 2005. View Article : Google Scholar : PubMed/NCBI
8	Siebert JD, Williams RP and Pulitzer DR: Myxoid liposarcoma with cartilaginous differentiation. Mod Pathol. 9:249–252. 1996.PubMed/NCBI
9	Dijkhuizen T, Molenaar WM, Hoekstra HJ, Wiersema J and van den Berg E: Cytogenetic analysis of a case of myxoid liposarcoma with cartilaginous differentiation. Cancer Genet Cytogenet. 92:141–143. 1996. View Article : Google Scholar : PubMed/NCBI
10	Wei YC, Li CF, Eng HL, Yeh MC, Lin CN and Huang HY: Myxoid liposarcoma with cartilaginous differentiation: Identification of the same type II TLS-CHOP fusion gene transcript in both lipogenic and chondroid components. Appl Immunohistochem Mol Morphol. 15:477–480. 2007. View Article : Google Scholar : PubMed/NCBI
11	Kim H, Hwangbo W, Ahn S, Kim S, Kim I and Kim CH: Myxoid liposarcoma with cartilaginous differentiation: A case study with cytogenetical analysis. Korean J Pathol. 47:284–288. 2013. View Article : Google Scholar : PubMed/NCBI
12	Ioannou MG, Kouvaras E, Papamichali R, Karachalios T and Koukoulis G: Myxoid liposarcoma with cartilaginous differentiation: A case study with fish analysis and review of the literature. Pathol Res Pract. 209:666–669. 2013. View Article : Google Scholar : PubMed/NCBI
13	Nishio J, Althof PA, Bailey JM, Zhou M, Neff JR, Barr FG, Parham DM, Teot L, Qualman SJ and Bridge JA: Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcoma. Lab Invest. 86:547–556. 2006.PubMed/NCBI
14	Simons A, Shaffer LG and Hastings RJ: Cytogenetic nomenclature: Changes in the ISCN 2013 compared to the 2009 edition. Cytogenet Genome Res. 141:1–6. 2013. View Article : Google Scholar : PubMed/NCBI
15	Yamaguchi U, Hasegawa T, Morimoto Y, Tateishi U, Endo M, Nakatani F, Kawai A, Chuman H, Beppu Y, Endo M, et al: A practical approach to the clinical diagnosis of Ewing's sarcoma/primitive neuroectodermal tumor and other small round cell tumors sharing EWS rearrangement using new fluorescence in situ hybridization probes for EWSR1 on formalin fixed, paraffin wax embedded tissue. J Clin Pathol. 58:1051–1056. 2005. View Article : Google Scholar : PubMed/NCBI
16	Nishida Y, Tsukushi S, Nakashima H and Ishiguro N: Clinicopathologic prognostic factors of pure myxoid liposarcoma of the extremities and trunk wall. Clin Orthop Relat Res. 468:3041–3046. 2010. View Article : Google Scholar : PubMed/NCBI
17	Fiore M, Grosso F, Lo Vullo S, Pennacchioli E, Stacchiotti S, Ferrari A, Collini P, Lozza L, Mariani L, Casali PG and Gronchi A: Myxoid/round cell and pleomorphic liposarcomas: Prognostic factors and survival in a series of patients treated at a single institution. Cancer. 109:2522–2531. 2007. View Article : Google Scholar : PubMed/NCBI
18	Tateishi U, Hasegawa T, Beppu Y, Kawai A and Moriyama N: Prognostic significance of grading (MIB-1 system) in patients with myxoid liposarcoma. J Clin Pathol. 56:579–582. 2003. View Article : Google Scholar : PubMed/NCBI
19	Enzinger FM and Shiraki M: Extraskeletal myxoid chondrosarcoma. An analysis of 34 cases. Hum Pathol. 3:421–435. 1972. View Article : Google Scholar : PubMed/NCBI
20	Weiss SW and Goldblum JR: Malignant mesenchymomaEnzinger and Weiss's Soft tissue tumors. 5th. Weiss SW Enzinger and Goldblum JR: Mosby Inc.; St. Louis: pp. 1213–1214. 2008
21	Riggi N, Cironi L, Provero P, Suvà ML, Stehle JC, Baumer K, Guillou L and Stamenkovic I: Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. Cancer Res. 66:7016–7023. 2006. View Article : Google Scholar : PubMed/NCBI
22	Rodriguez R, Rubio R, Gutierrez-Aranda I, Melen GJ, Elosua C, García-Castro J and Menendez P: FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells. Stem Cells. 29:179–192. 2011. View Article : Google Scholar : PubMed/NCBI
23	Suzuki K, Matsui Y, Higashimoto M, Kawaguchi Y, Seki S, Motomura H, Hori T, Yahara Y, Kanamori M and Kimura T: Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells. PLoS One. 7:e366822012. View Article : Google Scholar : PubMed/NCBI