Myxoid liposarcoma with cartilaginous differentiation showing DDIT3 rearrangement

  • Authors:
    • Kayo Suzuki
    • Taketoshi Yasuda
    • Kenta Watanabe
    • Takeshi Hori
    • Masahiko Kanamori
    • Tomoatsu Kimura
  • View Affiliations

  • Published online on: September 25, 2017     https://doi.org/10.3892/ol.2017.7056
  • Pages:6789-6794
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Abstract

Myxoid liposarcoma (MLPS) is the second most common histologic subtype of liposarcoma. However, cartilaginous differentiation within MLPS is an extremely rare phenomenon, with only 7 cases of MLPS with cartilaginous differentiation reported to date. The majority of MLPS cases show the t(12;16)(q13;p11) translocation, resulting in the fused in sarcoma‑DNA damage‑inducible transcript 3 (FUS‑DDIT3) fusion gene. This fusion gene as a hallmark of MLPS is very useful for differential diagnosis from other soft tissue sarcomas, and the associated protein, FUS‑DDIT3, performs an important role in the phenotypic selection of targeted multipotent mesenchymal cells during oncogenesis. In this report, a case of MLPS with cartilaginous differentiation that occurred in the thigh of a 44‑year‑old woman is described. Histopathologically, the tumor was composed of a typical myxoid liposarcoma area and a mature hyaline cartilaginous area. Using fluorescence in situ hybridization analysis, rearrangement of the DDIT3 gene was detected in not only the liposarcomatous area but also in the chondrocytes of the cartilaginous area. Based on these findings, the cartilaginous differentiation area appears to be partially associated with oncogenesis through the specific fusion gene FUS‑DDIT3.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Suzuki, K., Yasuda, T., Watanabe, K., Hori, T., Kanamori, M., & Kimura, T. (2017). Myxoid liposarcoma with cartilaginous differentiation showing DDIT3 rearrangement. Oncology Letters, 14, 6789-6794. https://doi.org/10.3892/ol.2017.7056
MLA
Suzuki, K., Yasuda, T., Watanabe, K., Hori, T., Kanamori, M., Kimura, T."Myxoid liposarcoma with cartilaginous differentiation showing DDIT3 rearrangement". Oncology Letters 14.6 (2017): 6789-6794.
Chicago
Suzuki, K., Yasuda, T., Watanabe, K., Hori, T., Kanamori, M., Kimura, T."Myxoid liposarcoma with cartilaginous differentiation showing DDIT3 rearrangement". Oncology Letters 14, no. 6 (2017): 6789-6794. https://doi.org/10.3892/ol.2017.7056