Beclin 1 expression is associated with the occurrence and development of esophageal squamous cell carcinoma

  • Authors:
    • Hailei Du
    • Jiamin Che
    • Minmin Shi
    • Lianggang Zhu
    • Jun Biao Hang
    • Zhongyuan Chen
    • Hecheng Li
  • View Affiliations

  • Published online on: September 21, 2017     https://doi.org/10.3892/ol.2017.7015
  • Pages:6823-6828
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Abstract

Beclin 1 has a central role in the regulation of autophagy, differentiation, apoptosis resistance, tumorigenesis and cancer progression. The role of Beclin 1 in the development of esophageal squamous cell carcinoma (ESCC) and its subsequent progression is not fully characterized. In the present study, the role of Beclin 1 and autophagy in ESCC was evaluated. The expression of Beclin 1 mRNA and protein levels in human ESCC tumor and adjacent normal esophageal tissue was measured. Beclin 1 mRNA and protein were significantly lower in tumor tissue than in normal esophageal tissue (P<0.05). Cells of the less differentiated esophageal tumors expressed lower Beclin 1 mRNA and protein (P<0.05). Tumors from patients in early clinical stages (I/II) exhibited significantly higher Beclin 1 mRNA and protein expression levels than patients with tumors in mid‑to‑late stages (III/IV; P<0.05). Tumors from patients with lymph node metastasis exhibited significantly lower Beclin 1 mRNA and protein expression levels compared with tumors from patients without lymph node involvement (P<0.05). Beclin 1 downregulation was demonstrated to significantly upregulate invasion by ESCC EC9706 cells (P<0.01), and downregulate the number of acidic vesicular organelles, a process associated with autophagy. These results suggest that the expression of Beclin 1 is associated with the occurrence and development of ESCC. Measuring the Beclin 1 expression of tumors from patient may improve the understanding of the prognosis of patients with ESCC.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Du, H., Che, J., Shi, M., Zhu, L., Hang, J.B., Chen, Z., & Li, H. (2017). Beclin 1 expression is associated with the occurrence and development of esophageal squamous cell carcinoma. Oncology Letters, 14, 6823-6828. https://doi.org/10.3892/ol.2017.7015
MLA
Du, H., Che, J., Shi, M., Zhu, L., Hang, J. B., Chen, Z., Li, H."Beclin 1 expression is associated with the occurrence and development of esophageal squamous cell carcinoma". Oncology Letters 14.6 (2017): 6823-6828.
Chicago
Du, H., Che, J., Shi, M., Zhu, L., Hang, J. B., Chen, Z., Li, H."Beclin 1 expression is associated with the occurrence and development of esophageal squamous cell carcinoma". Oncology Letters 14, no. 6 (2017): 6823-6828. https://doi.org/10.3892/ol.2017.7015