Beclin‑1 suppresses gastric cancer progression by promoting apoptosis and reducing cell migration
- Yanfeng Wang
- Jianying Xie
- Hao Wang
- Haixia Huang
- Ping Xie
Published online on: September 25, 2017
To investigate Beclin‑1 expression in gastric cancer and its clinical relevance, 60 samples were collected from patients with gastric carcinoma, which were subjected to immunohistochemical staining and analysis. Associations of Beclin‑1 expression with the clinical parameters of the patients, including tumor size, histological differentiation and metastatic status, were examined by statistical analysis. The results demonstrated that Beclin‑1 expression in gastric carcinoma tissue was significantly associated with the tumor, node, metastasis stage and tumor invasion status. Further experiments indicated that Beclin‑1 overexpression promoted MKN‑45 gastric cancer cell apoptosis and inhibited their migration. These data suggested that Beclin‑1 was a suppressor of tumorigenesis in gastric cancer and a potential therapeutic target for patients with gastric cancer.