Beclin‑1 suppresses gastric cancer progression by promoting apoptosis and reducing cell migration

  • Authors:
    • Yanfeng Wang
    • Jianying Xie
    • Hao Wang
    • Haixia Huang
    • Ping Xie
  • View Affiliations

  • Published online on: September 25, 2017     https://doi.org/10.3892/ol.2017.7046
  • Pages:6857-6862
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Abstract

To investigate Beclin‑1 expression in gastric cancer and its clinical relevance, 60 samples were collected from patients with gastric carcinoma, which were subjected to immunohistochemical staining and analysis. Associations of Beclin‑1 expression with the clinical parameters of the patients, including tumor size, histological differentiation and metastatic status, were examined by statistical analysis. The results demonstrated that Beclin‑1 expression in gastric carcinoma tissue was significantly associated with the tumor, node, metastasis stage and tumor invasion status. Further experiments indicated that Beclin‑1 overexpression promoted MKN‑45 gastric cancer cell apoptosis and inhibited their migration. These data suggested that Beclin‑1 was a suppressor of tumorigenesis in gastric cancer and a potential therapeutic target for patients with gastric cancer.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Wang, Y., Xie, J., Wang, H., Huang, H., & Xie, P. (2017). Beclin‑1 suppresses gastric cancer progression by promoting apoptosis and reducing cell migration. Oncology Letters, 14, 6857-6862. https://doi.org/10.3892/ol.2017.7046
MLA
Wang, Y., Xie, J., Wang, H., Huang, H., Xie, P."Beclin‑1 suppresses gastric cancer progression by promoting apoptosis and reducing cell migration". Oncology Letters 14.6 (2017): 6857-6862.
Chicago
Wang, Y., Xie, J., Wang, H., Huang, H., Xie, P."Beclin‑1 suppresses gastric cancer progression by promoting apoptosis and reducing cell migration". Oncology Letters 14, no. 6 (2017): 6857-6862. https://doi.org/10.3892/ol.2017.7046