Expression and prognostic significance of cyclin‑dependent kinase inhibitor 1A in patients with resected gastric adenocarcinoma

  • Authors:
    • Youdong Lin
    • Xiaoting Wang
    • Yinghao Yu
    • Wei Liu
    • Feilai Xie
    • Xuenong Ouyang
    • Qiaojia Huang
  • View Affiliations

  • Published online on: September 29, 2017     https://doi.org/10.3892/ol.2017.7107
  • Pages:7473-7482
0

Abstract

Cyclin‑dependent kinase inhibitor 1A (CDKN1A) is an important cell cycleregulator, and has been identified to exhibit aberrant expression in various types of cancer tissues. However, the association between CDKN1A expression level and prognosis in patients with resected gastric adenocarcinoma (RGA) requires additional elucidation. In the present study, the CDKN1A expression profile in RGA tissues obtained from 217 patients were analyzed using immunohistochemistry. Its prognostic significance was evaluated by using the χ2 test, Kaplan‑Meier curves and the log‑rank test, and a multivariate Cox model analysis, during a median follow‑up time of 51 months. The results demonstrated that CDKN1A expression was significantly correlated with lymph node metastasis (LNM; P=0.001), recurrence (P<0.001) and overall survival (OS; P<0.001). In addition, the recurrence‑free survival (RFS) and OS times were significantly shorter in patients with low CDKN1A expression compared with those with high CDKN1A expression (RFS, 20 months vs. 69 months, P<0.001; and OS, 32 months vs. 70 months, P<0.001, respectively). Multivariate analysis additionally confirmed that low CDKN1A expression was significantly correlated with an increased risk of LNM (P=0.001), recurrence (P<0.001) and mortality (P<0.001). Therefore, these data suggest that low expression of CDKN1A has independent prognostic significance indicative of tumor progression and poor survival in patients with RGA. Evaluation of CDKN1A expression may assist in determining prognosis in patients with RGA.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Lin, Y., Wang, X., Yu, Y., Liu, W., Xie, F., Ouyang, X., & Huang, Q. (2017). Expression and prognostic significance of cyclin‑dependent kinase inhibitor 1A in patients with resected gastric adenocarcinoma. Oncology Letters, 14, 7473-7482. https://doi.org/10.3892/ol.2017.7107
MLA
Lin, Y., Wang, X., Yu, Y., Liu, W., Xie, F., Ouyang, X., Huang, Q."Expression and prognostic significance of cyclin‑dependent kinase inhibitor 1A in patients with resected gastric adenocarcinoma". Oncology Letters 14.6 (2017): 7473-7482.
Chicago
Lin, Y., Wang, X., Yu, Y., Liu, W., Xie, F., Ouyang, X., Huang, Q."Expression and prognostic significance of cyclin‑dependent kinase inhibitor 1A in patients with resected gastric adenocarcinoma". Oncology Letters 14, no. 6 (2017): 7473-7482. https://doi.org/10.3892/ol.2017.7107