Open Access

Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer

  • Authors:
    • Hui Xiong
    • Jiangnan Zhang
  • View Affiliations

  • Published online on: October 13, 2017     https://doi.org/10.3892/ol.2017.7181
  • Pages:7825-7828
  • Copyright: © Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The expression of ataxia-telangiectasia mutated (ATM) and p53 upregulated modulator of apoptosis (PUMA) genes in patients with colorectal cancer were investigated, to explore the correlation between the expression of ATM and PUMA and tumor development, to evaluate the clinical significance of ATM and PUMA in the treatment of colorectal cancer. Quantitative real-time PCR was used to detect the expression of ATM and PUMA in tumor tissue and adjacent healthy tissue of 67 patients with colorectal cancer and in normal colorectal tissue of 33 patients with colorectal polyps at mRNA level. The expression level of ATM mRNA in colorectal cancer tissues was significantly higher than that in normal mucosa tissues and adjacent non‑cancerous tissue (P≤0.05), while no significant differences in expression level of ATM mRNA were found between normal mucosa tissues and adjacent noncancerous tissue (P=0.07). There was a negative correlation between the expression of ATM mRNA and the degree of differentiation of colorectal cancer (r= -0.312, P=0.013), while expression level of ATM mRNA was not significantly correlated with the age, sex, tumor invasion, lymph node metastasis or clinical stage (P>0.05). Expression levels of PUMA mRNA in colorectal cancer tissues, adjacent noncancerous tissue and normal tissues were 0.68±0.07, 0.88±0.04 and 1.76±0.06, respectively. Expression level of PUMA mRNA in colorectal cancer tissues and adjacent noncancerous tissue was significantly lower than that in normal colorectal tissues (P<0.05). The results showed that ATM mRNA is expressed abnormally in colorectal cancer tissues. Expression of PUMA gene in colorectal carcinoma is downregulated, and is negatively correlated with the occurrence of cancer.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Xiong, H., & Xiong, H. (2017). Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer. Oncology Letters, 14, 7825-7828. https://doi.org/10.3892/ol.2017.7181
MLA
Xiong, H., Zhang, J."Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer". Oncology Letters 14.6 (2017): 7825-7828.
Chicago
Xiong, H., Zhang, J."Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer". Oncology Letters 14, no. 6 (2017): 7825-7828. https://doi.org/10.3892/ol.2017.7181