Imbalance in circulatory iNKT, Th17 and T regulatory cell frequencies in patients with B‑cell non‑Hodgkin's lymphoma

  • Authors:
    • Iwona Hus
    • Agnieszka Bojarska‑Junak
    • Marzena Kamińska
    • Aneta Dobrzyńska‑Rutkowska
    • Karolina Szatan
    • Agnieszka Szymczyk
    • Bożena Kukiełka‑Budny
    • Dariusz Szczepanek
    • Jacek Roliński
  • View Affiliations

  • Published online on: October 20, 2017     https://doi.org/10.3892/ol.2017.7232
  • Pages:7957-7964
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Abstract

T cells are important in B‑cell non‑Hodgkin's lymphoma immunity, however the function of T cell subsets, including natural killer (iNKT), T helper (Th)17, and T regulatory cells remains to be elucidated. The present study analyzed the frequencies of iNKT, Th17 and T regulatory cells in the peripheral blood of 41 patients with B‑cell non‑Hodgkin lymphoma at diagnosis, then during and following immunochemotherapy R‑CHOP/R‑CVP. At lymphoma diagnosis, iNKT and Th17 frequencies were decreased and T regulatory cell frequencies were increased compared with healthy control group. The Th17 cell percentage was lower in patients with a worse prognosis and at a more advanced clinical stage and in contrast, the percentage of T regulatory cells was increased in patients at advanced stages of lymphoma, compared to earlier stages. There was an increase of iNKT and Th17 cells following R‑CHOP/R‑CVP therapy. In patients that responded, both prior to and following‑treatment, percentages of iNKT and Th17 were higher and T regulatory cells were lower compared with patients with subsequent disease progression. Taken together, the results obtained demonstrated the opposing effects of T cell subsets in B‑cell lymphoma immunity, with iNKT and Th17 inhibiting and T regulatory cells enhancing tumor growth. These alterations may be caused by malignant B‑cells, however there may also be an axis of inverse feedback between T regulatory cells and their interaction with Th17 and iNKT cells.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Hus, I., Bojarska‑Junak, A., Kamińska, M., Dobrzyńska‑Rutkowska, A., Szatan, K., Szymczyk, A. ... Roliński, J. (2017). Imbalance in circulatory iNKT, Th17 and T regulatory cell frequencies in patients with B‑cell non‑Hodgkin's lymphoma. Oncology Letters, 14, 7957-7964. https://doi.org/10.3892/ol.2017.7232
MLA
Hus, I., Bojarska‑Junak, A., Kamińska, M., Dobrzyńska‑Rutkowska, A., Szatan, K., Szymczyk, A., Kukiełka‑Budny, B., Szczepanek, D., Roliński, J."Imbalance in circulatory iNKT, Th17 and T regulatory cell frequencies in patients with B‑cell non‑Hodgkin's lymphoma". Oncology Letters 14.6 (2017): 7957-7964.
Chicago
Hus, I., Bojarska‑Junak, A., Kamińska, M., Dobrzyńska‑Rutkowska, A., Szatan, K., Szymczyk, A., Kukiełka‑Budny, B., Szczepanek, D., Roliński, J."Imbalance in circulatory iNKT, Th17 and T regulatory cell frequencies in patients with B‑cell non‑Hodgkin's lymphoma". Oncology Letters 14, no. 6 (2017): 7957-7964. https://doi.org/10.3892/ol.2017.7232