Thalidomide inhibits proliferation and epithelial‑mesenchymal transition by modulating CD133 expression in pancreatic cancer cells

  • Authors:
    • Congying Chen
    • Ge Yu
    • Wenqin Xiao
    • Miao Xing
    • Jianbo Ni
    • Rong Wan
    • Guoyong Hu
  • View Affiliations

  • Published online on: October 18, 2017     https://doi.org/10.3892/ol.2017.7213
  • Pages:8206-8212
Metrics: PDF 0 views | HTML 0 views
0

Abstract

Pancreatic cancer is a solid malignancy with a high mortality rate, on account of the high incidence of metastasis at the time of detection. The aggressiveness of pancreatic cancer may be partly driven by cancer stem cells (CSCs), which are characterized by the ability to self‑renew and recapitulate tumors in the ectopic setting. However, although a number of drugs targeting CSCs are currently under clinical investigation, few effective drugs have been developed. The present study demonstrated that thalidomide inhibited cell proliferation and metastasis in pancreatic cancer cell lines through the inhibition of epithelial mesenchymal transition. The effect of thalidomide was more pronounced in cluster of differentiation 133 (CD133)+ SW1990 cells than in Capan‑2 cells, in which CD133 expression was almost undetectable. The results revealed that CD133 is likely to serve a role in the antitumor effect of thalidomide and indicated that thalidomide could be developed as a CSC‑specific adjuvant chemotherapy in pancreatic cancer.

Related Articles

Journal Cover

December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Chen, C., Yu, G., Xiao, W., Xing, M., Ni, J., Wan, R., & Hu, G. (2017). Thalidomide inhibits proliferation and epithelial‑mesenchymal transition by modulating CD133 expression in pancreatic cancer cells. Oncology Letters, 14, 8206-8212. https://doi.org/10.3892/ol.2017.7213
MLA
Chen, C., Yu, G., Xiao, W., Xing, M., Ni, J., Wan, R., Hu, G."Thalidomide inhibits proliferation and epithelial‑mesenchymal transition by modulating CD133 expression in pancreatic cancer cells". Oncology Letters 14.6 (2017): 8206-8212.
Chicago
Chen, C., Yu, G., Xiao, W., Xing, M., Ni, J., Wan, R., Hu, G."Thalidomide inhibits proliferation and epithelial‑mesenchymal transition by modulating CD133 expression in pancreatic cancer cells". Oncology Letters 14, no. 6 (2017): 8206-8212. https://doi.org/10.3892/ol.2017.7213