Network analysis revealed aurora kinase dysregulation in five gynecological types of cancer

  • Authors:
    • Shikha Suman
    • Ashutosh Mishra
  • View Affiliations

  • Published online on: November 8, 2017     https://doi.org/10.3892/ol.2017.7368
  • Pages:1125-1132
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Abstract

Gene markers are crucial for cancer prognosis and treatment. Previous studies have placed greater emphasis on individual diagnostic genes, thereby ignoring systemic‑level attributes across diseases. Female‑specific cells namely, breast, endometrium, cervical, ovarian and vulvar cells are highly susceptible to cancer. To date, a limited number of molecular studies have been performed that evaluate common biological processes across gynecological types of cancer. Differentially expressed genes in breast, cervical, endometrial, vulvar and ovarian cancer were utilized to construct protein‑protein interaction networks, and to identify a common module across the five cancer types. A single common module with 8 nodes and 26 edges was mined among the five cancer systems. In total, four hub genes were present across the five cancer gene sets. Genes in the common module were enriched for the common pathways and associated diseases. The aurora kinase pathway was revealed to be conserved across the five cancer types surveyed. The present study, therefore, revealed that the aurora kinase pathway has a crucial function in the pathogenesis of the five aforementioned gynecological types of cancer through cross‑tumor conservation.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Suman, S., & Suman, S. (2018). Network analysis revealed aurora kinase dysregulation in five gynecological types of cancer. Oncology Letters, 15, 1125-1132. https://doi.org/10.3892/ol.2017.7368
MLA
Suman, S., Mishra, A."Network analysis revealed aurora kinase dysregulation in five gynecological types of cancer". Oncology Letters 15.1 (2018): 1125-1132.
Chicago
Suman, S., Mishra, A."Network analysis revealed aurora kinase dysregulation in five gynecological types of cancer". Oncology Letters 15, no. 1 (2018): 1125-1132. https://doi.org/10.3892/ol.2017.7368