G‑CSF producing oral carcinoma with diffuse uptake of FDG in the bone marrow: A case report
- Takeshi Kuroshima
- Mayumi Wada
- Takehiko Sato
- Masashi Takano
- Shujiroh Makino
Published online on: November 15, 2017
A 78‑year‑old male patient was referred to the Department of Oral Surgery, Hokuto Hospital (Obihiro, Japan) for painless swelling on the left neck and tongue. Histopathological examination of a biopsy specimen resulted in a diagnosis of squamous cell carcinoma of the tongue. Imaging examinations revealed cervical lymph node metastases on both sides, along with diffuse uptake of 18F‑fluorodeoxyglucose (FDG) in the bone marrow of the spine and pelvis. Hematologic tests revealed an increased white blood cell (WBC) count and serum concentrations of granulocyte colony stimulating factor (G‑CSF). These findings suggested a G‑CSF producing tumor, with fluctuations of WBC count, serum G‑CSF concentration, and FDG uptake in the bone marrow, associated with tumor shrinkage and enlargement, an indicator of tumor status.