G‑CSF producing oral carcinoma with diffuse uptake of FDG in the bone marrow: A case report

Kuroshima,Takeshi; Wada,Mayumi; Sato,Takehiko; Takano,Masashi; Makino,Shujiroh

doi:10.3892/ol.2017.7422

G‑CSF producing oral carcinoma with diffuse uptake of FDG in the bone marrow: A case report

Authors:
- Takeshi Kuroshima
- Mayumi Wada
- Takehiko Sato
- Masashi Takano
- Shujiroh Makino
View Affiliations

Affiliations: Oral and Maxillofacial Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113‑8549, Japan, Department of Oral Surgery, Hokuto Hospital, Obihiro, Hokkaido 080-0833 Japan
Published online on: November 15, 2017 https://doi.org/10.3892/ol.2017.7422
Pages: 1241-1245

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

A 78‑year‑old male patient was referred to the Department of Oral Surgery, Hokuto Hospital (Obihiro, Japan) for painless swelling on the left neck and tongue. Histopathological examination of a biopsy specimen resulted in a diagnosis of squamous cell carcinoma of the tongue. Imaging examinations revealed cervical lymph node metastases on both sides, along with diffuse uptake of 18F‑fluorodeoxyglucose (FDG) in the bone marrow of the spine and pelvis. Hematologic tests revealed an increased white blood cell (WBC) count and serum concentrations of granulocyte colony stimulating factor (G‑CSF). These findings suggested a G‑CSF producing tumor, with fluctuations of WBC count, serum G‑CSF concentration, and FDG uptake in the bone marrow, associated with tumor shrinkage and enlargement, an indicator of tumor status.

View Figures

View References

1	Kumar AK, Satyan MT, Holzbeierlein J, Mirza M and Van Veldhuizen P: Leukemoid reaction and autocrine growth of bladder cancer induced by paraneoplastic production of granulocyte colony-stimulating factor-a potential neoplastic marker: A case report and review of the literature. J Med Case Rep. 8:1472014. View Article : Google Scholar : PubMed/NCBI
2	Morooka M, Kubota K, Murata Y, Shibuya H, Ito K, Mochizuki M, Akashi T, Chiba T, Nomura T, Ito H and Morita T: (18)F-FDG-PET/CT findings of granulocyte colony stimulating factor (G-CSF)-producing lung tumors. Ann Nucl Med. 22:635–639. 2008. View Article : Google Scholar : PubMed/NCBI
3	Asano S, Urabe A, Okabe T, Sato N and Kondo Y: Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood. 49:845–852. 1977.PubMed/NCBI
4	Kobayashi J, Miyazaki A, Yamamot T, Nakamori K, Suzuki R, Kaneko T, Suzuki N and Hiratsuka H: Granulocyte colony-stimulating factor-producing squamous cell carcinoma of the lower gingiva: A case report. Head Neck Oncol. 4:352012. View Article : Google Scholar : PubMed/NCBI
5	Kawaguchi M, Asada Y, Terada T, Takehara A, Munemoto Y, Fujisawa K, Mitsui T, Iida Y, Miura S and Sudo Y: Aggressive recurrence of gastric cancer as a granulocyte-colony-stimulating factor-producing tumor. Int J Clin Oncol. 15:191–195. 2010. View Article : Google Scholar : PubMed/NCBI
6	Vinzens S, Zindel J, Zweifel M, Rau T, Gloor B and Wochner A: Granulocyte colony-stimulating factor producing anaplastic carcinoma of the pancreas: Case report and review of the literature. Anticancer Res. 37:223–228. 2017. View Article : Google Scholar : PubMed/NCBI
7	Horii A, Shimamura K, Honjo Y, Mitani K, Miki T, Takashima S and Yoshida J: Granulocyte colony stimulating factor-producing tongue carcinoma. Head Neck. 19:351–356. 1997. View Article : Google Scholar : PubMed/NCBI
8	Murata Y, Kubota K, Yukihiro M, Ito K, Watanabe H and Shibuya H: Correlations between 18F-FDG uptake by bone marrow and hematological parameters: Measurements by PET/CT. Nucl Med Biol. 33:999–1004. 2006. View Article : Google Scholar : PubMed/NCBI
9	Sugawara Y, Zasadny KR, Kison PV, Baker LH and Wahl RL: Splenic fluorodeoxyglucose uptake increased by granulocyte colony-stimulating factor therapy: PET imaging results. J Nucl Med. 40:1456–1462. 1999.PubMed/NCBI
10	Goshen E, Davidson T, Yeshurun M and Zwas ST: Combined increased and decreased skeletal uptake of F-18 FDG. Clin Nucl Med. 31:520–522. 2006. View Article : Google Scholar : PubMed/NCBI
11	Nagata H, Komatsu S, Takaki W, Okayama T, Sawabe Y, Ishii M, Kishimoto M, Otsuji E and Konosu H: Granulocyte colony-stimulating factor-producing hepatocellular carcinoma with abrupt changes. World J Clin Oncol. 7:380–386. 2016. View Article : Google Scholar : PubMed/NCBI
12	Kaneko N, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, Sakamoto T, Hashiguchi Y, Iida M and Nakamura S: Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte colony-stimulating factor: A case report and literature review. World J Surg Oncol. 14:1612016. View Article : Google Scholar : PubMed/NCBI
13	Ishigami T, Yoshida H, Yusa H and Yanagawa T: Gingival cancer suspected of producing granulocyte colony-stimulating factor: Report of a case. J Oral Maxillofac Surg. 59:804–808. 2001. View Article : Google Scholar : PubMed/NCBI
14	Yazawa S, Toshimori H, Nakatsuru K, Katakami H, Takemura J and Matsukura S: Thyroid anaplastic carcinoma producing granulocyte-colony-stimulating factor and parathyroid hormone-related protein. Intern Med. 34:584–588. 1995. View Article : Google Scholar : PubMed/NCBI
15	Yoneda T, Nishimura R, Kato I, Ohmae M, Takita M and Sakuda M: Frequency of the hypercalcemia-leukocytosis syndrome in oral malignancies. Cancer. 68:617–622. 1991. View Article : Google Scholar : PubMed/NCBI
16	Tanaka K and Nibu K: Laryngeal squamous cell carcinoma with ectopic production of granulocyte colony-stimulating factor and parathyroid hormone-related protein. Int J Clin Oncol. 10:195–197. 2005. View Article : Google Scholar : PubMed/NCBI
17	Tamura K, Yoshinaga T, Tanino M, Kimura T, Yamada N, Nishimura M, Fukuda S, Nishihara H, Shindoh M and Tanaka S: Hypopharyngeal squamous cell carcinoma producing both granulocyte colony-stimulating factor and parathyroid hormone-related protein. Pathol Int. 58:652–656. 2008. View Article : Google Scholar : PubMed/NCBI
18	Inoue M, Minami M, Fujii Y, Matsuda H, Shirakura R and Kido T: Granulocyte colony-stimulating factor and interleukin-6-producing lung cancer cell line, LCAM. J Surg Oncol. 64:347–350. 1997. View Article : Google Scholar : PubMed/NCBI
19	Ichiishi E, Yoshikawa T, Kogawa T, Yoshida N and Kondo M: Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus. Gut. 46:432–434. 2000. View Article : Google Scholar : PubMed/NCBI
20	Natori T, Sata M, Washida M, Hirata Y, Nagai R and Makuuchi M: G-CSF stimulates angiogenesis and promotes tumor growth: Potential contribution of bone marrow-derived endothelial progenitor cells. Biochem Biophys Res Commun. 297:1058–1061. 2002. View Article : Google Scholar : PubMed/NCBI