Ang1/Tie2 induces cell proliferation and migration in human papillary thyroid carcinoma via the PI3K/AKT pathway

  • Authors:
    • Ke Ye
    • Jindong Li
    • Xinying Li
    • Shi Chang
    • Zhejia Zhang
  • View Affiliations

  • Published online on: November 8, 2017     https://doi.org/10.3892/ol.2017.7367
  • Pages:1313-1318
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Abstract

The angiopoietin 1 (Ang1)/angiopoietin receptor (Tie2) signaling pathway may have a notable role in the pathogenesis of inflammatory diseases. The abnormal expression of angiopoietin 1 and Tie2 has also been reported in various malignant tumors, including papillary thyroid carcinoma (PTC). However, the role and mechanism of the Ang1/Tie2 pathway in the progression of PTC remains unclear. Therefore, the aims of the present study were to clarify this. Significantly high expression levels of Ang1 and Tie2 were observed in PTC tissues and cell lines. Furthermore, MTT and wound‑healing assays revealed that the Ang1‑mediated stimulation of human PTC cells resulted in increased proliferation and migration. Conversely, the downregulation of Tie2 levels using short hairpin RNA targeted at Tie2 abrogated the Ang1‑mediated effect on cell proliferation and migration. In studying the expression of phosphoinositide‑3 kinase (PI3K)/RAC serine/threonine‑protein kinase (Akt) pathway, the upregulation of Ang1/Tie2 was found to be associated with the activation of the PI3K/Akt pathway in PTC. In conclusion, the data from the present study indicated that the Ang1/Tie2 induces PTC oncogenesis via the PI3K/Akt pathway, providing novel insights into human PTC therapy.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Ye, K., Li, J., Li, X., Chang, S., & Zhang, Z. (2018). Ang1/Tie2 induces cell proliferation and migration in human papillary thyroid carcinoma via the PI3K/AKT pathway. Oncology Letters, 15, 1313-1318. https://doi.org/10.3892/ol.2017.7367
MLA
Ye, K., Li, J., Li, X., Chang, S., Zhang, Z."Ang1/Tie2 induces cell proliferation and migration in human papillary thyroid carcinoma via the PI3K/AKT pathway". Oncology Letters 15.1 (2018): 1313-1318.
Chicago
Ye, K., Li, J., Li, X., Chang, S., Zhang, Z."Ang1/Tie2 induces cell proliferation and migration in human papillary thyroid carcinoma via the PI3K/AKT pathway". Oncology Letters 15, no. 1 (2018): 1313-1318. https://doi.org/10.3892/ol.2017.7367