Crosstalk between the Notch signaling pathway and non‑coding RNAs in gastrointestinal cancers (Review)

  • Authors:
    • Yangyang Pan
    • Yuyan Mao
    • Rong Jin
    • Lei Jiang
  • View Affiliations

  • Published online on: October 30, 2017     https://doi.org/10.3892/ol.2017.7294
  • Pages:31-40
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Abstract

The Notch signaling pathway is one of the main signaling pathways that mediates direct contact between cells, and is essential for normal development. It regulates various cellular processes, including cell proliferation, apoptosis, migration, invasion, angiogenesis and metastasis. It additionally serves an important function in tumor progression. Non‑coding RNAs mainly include small microRNAs, long non‑coding RNAs and circular RNAs. At present, a large body of literature supports the biological significance of non‑coding RNAs in tumor progression. It is also becoming increasingly evident that cross‑talk exists between Notch signaling and non‑coding RNAs. The present review summarizes the current knowledge of Notch‑mediated gastrointestinal cancer cell processes, and the effect of the crosstalk between the three major types of non‑coding RNAs and the Notch signaling pathway on the fate of gastrointestinal cancer cells.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

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APA
Pan, Y., Mao, Y., Jin, R., & Jiang, L. (2018). Crosstalk between the Notch signaling pathway and non‑coding RNAs in gastrointestinal cancers (Review). Oncology Letters, 15, 31-40. https://doi.org/10.3892/ol.2017.7294
MLA
Pan, Y., Mao, Y., Jin, R., Jiang, L."Crosstalk between the Notch signaling pathway and non‑coding RNAs in gastrointestinal cancers (Review)". Oncology Letters 15.1 (2018): 31-40.
Chicago
Pan, Y., Mao, Y., Jin, R., Jiang, L."Crosstalk between the Notch signaling pathway and non‑coding RNAs in gastrointestinal cancers (Review)". Oncology Letters 15, no. 1 (2018): 31-40. https://doi.org/10.3892/ol.2017.7294