Total alkaloids of Corydalis saxicola bunting inhibits migration of A549 cells by suppressing Cdc42 or Vav1

  • Authors:
    • Mimi Li
    • Jiying Wang
    • Biwen Mo
    • Jinrong Zeng
    • Dong Yao
    • Feng Chen
    • Ming Jiang
    • Lizong Rao
    • Yinjun Du
  • View Affiliations

  • Published online on: October 26, 2017     https://doi.org/10.3892/ol.2017.7273
  • Pages:475-482
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Abstract

Cell division cycle 42 (Cdc42) is a critical regulator, which functions in cancer metastasis. Numerous previous studies have demonstrated that vav guanine nucleotide exchange factor 1 (Vav1) is ectopically expressed in numerous types of human malignancies and have suggested that Vav1 may efficiently promote the formation of invadopodia and matrix degradation by regulating the activation of Cdc42. Total alkaloids of Corydalis saxicola bunting (TAOCSB), a type of alkaloid compound extracted from the root of C. saxicola bunting, has been revealed to have anticancer properties. However, there is no available information to address the effects of TAOCSB on the metastasis of human lung cancer. In the present study, the anticancer effect on A549 non‑small cell lung cancer cells induced by TAOCSB was investigated, as well as its underlying mechanisms. The results demonstrated that a low dose of TAOCSB exhibited anti‑metastatic potential in suppressing the invasion and migration of A549 cells, and this action may be involved in TAOCSB‑mediated inhibition of Cdc42 expression at the level of mRNA and protein in parallel with TAOCSB‑mediated inhibition of matrix metalloproteinase (MMP)‑2 and MMP‑9 protein expression levels. Although the present study did not reveal the expression level of Vav1 protein in A549 cells, the expression level of Vav1 mRNA was investigated. The effect of Vav1 expression in A549 cells requires further study. Overall, the results of the present study revealed that TAOCSB may provide more information regarding lung cancer treatment.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Li, M., Wang, J., Mo, B., Zeng, J., Yao, D., Chen, F. ... Du, Y. (2018). Total alkaloids of Corydalis saxicola bunting inhibits migration of A549 cells by suppressing Cdc42 or Vav1. Oncology Letters, 15, 475-482. https://doi.org/10.3892/ol.2017.7273
MLA
Li, M., Wang, J., Mo, B., Zeng, J., Yao, D., Chen, F., Jiang, M., Rao, L., Du, Y."Total alkaloids of Corydalis saxicola bunting inhibits migration of A549 cells by suppressing Cdc42 or Vav1". Oncology Letters 15.1 (2018): 475-482.
Chicago
Li, M., Wang, J., Mo, B., Zeng, J., Yao, D., Chen, F., Jiang, M., Rao, L., Du, Y."Total alkaloids of Corydalis saxicola bunting inhibits migration of A549 cells by suppressing Cdc42 or Vav1". Oncology Letters 15, no. 1 (2018): 475-482. https://doi.org/10.3892/ol.2017.7273