Identification of expression quantitative trait loci of MTOR associated with the progression of glioma

  • Authors:
    • Liming Huang
    • Lian Dai
    • Wenshen Xu
    • Shu Zhang
    • Danfang Yan
    • Xi Shi
  • View Affiliations

  • Published online on: November 1, 2017     https://doi.org/10.3892/ol.2017.7319
  • Pages:665-671
Metrics: HTML 0 views | PDF 0 views     Cited By: 0 citations

Abstract

Mechanistic target of rapamycin (MTOR) encodes a key modulator of cell growth, proliferation, and apoptosis. Previous studies have demonstrated that the dysregulation of MTOR is involved in the development and progression of several types of cancer, including glioma. In the present study, a comprehensive analysis was conducted to examine whether the expression quantitative trait loci (eQTLs) of MTOR are associated with the progression of glioma. Candidate eQTLs of MTOR were obtained from the Genotype‑Tissue Expression eQTL Browser. The Kaplan‑Meier method and multivariate Cox model were used to analyze the progression‑free survival time of glioma patients. Based on the analysis of 138 glioma patients, one eQTL of MTOR, rs4845964, was demonstrated to be significantly associated with the progression of glioma in a dominant manner. The adjusted hazard ratios (HRs) for patients with the AG or AA genotype at rs4845964 were 2.82 [95% confidence interval (CI), 1.27‑6.27; P=0.0111] and 2.79 (95% CI, 1.10‑7.07; P=0.0312), respectively, compared with those with the GG genotype. When the rs4845964 AG and AA genotypes were combined for analysis, the HR was 2.70 (95% CI, 1.25‑5.82; P=0.0114) vs. the GG genotype. Stratified analyses revealed similar associations between the rs4845964 genotypes and the progression of glioma in all subgroups (following stratification by age, sex and tumor grade). These results demonstrate for the first time that the MTOR eQTL rs4845964 is associated with the progression of glioma.

Related Articles

Journal Cover

January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Huang, L., Dai, L., Xu, W., Zhang, S., Yan, D., & Shi, X. (2018). Identification of expression quantitative trait loci of MTOR associated with the progression of glioma. Oncology Letters, 15, 665-671. https://doi.org/10.3892/ol.2017.7319
MLA
Huang, L., Dai, L., Xu, W., Zhang, S., Yan, D., Shi, X."Identification of expression quantitative trait loci of MTOR associated with the progression of glioma". Oncology Letters 15.1 (2018): 665-671.
Chicago
Huang, L., Dai, L., Xu, W., Zhang, S., Yan, D., Shi, X."Identification of expression quantitative trait loci of MTOR associated with the progression of glioma". Oncology Letters 15, no. 1 (2018): 665-671. https://doi.org/10.3892/ol.2017.7319