Open Access

Expression levels of UL16 binding protein 1 and natural killer group 2 member D affect overall survival in patients with gastric cancer following gastrectomy

  • Authors:
    • Ryoji Kamei
    • Kiyoshi Yoshimura
    • Shigefumi Yoshino
    • Moeko Inoue
    • Tetsuhiko Asao
    • Masanori Fuse
    • Satoshi Wada
    • Atsuo Kuramasu
    • Tomoko Furuya‑Kondo
    • Atsunori Oga
    • Norio Iizuka
    • Nobuaki Suzuki
    • Noriko Maeda
    • Yusaku Watanabe
    • Satoshi Matsukuma
    • Michihisa Iida
    • Shigeru Takeda
    • Tomio Ueno
    • Noboru Yamamoto
    • Takeo Fukagawa
    • Hitoshi Katai
    • Hiroki Sasaki
    • Shoichi Hazama
    • Masaaki Oka
    • Hiroaki Nagano
  • View Affiliations

  • Published online on: November 6, 2017     https://doi.org/10.3892/ol.2017.7354
  • Pages:747-754
  • Copyright: © Kamei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

UL16 binding protein 1 (ULBP1) expressed on the tumor cell surface binds to the natural killer group 2 member D (NKG2D) receptor presenting on natural killer (NK), cluster of differentiation (CD)8+ T, and γ δ T cells. However, the roles of ULBP1 and NKG2D expression and associated immune responses in gastric cancer are unclear. The present study investigated the associations between ULBP1 and NKG2D expression and clinical outcomes in patients with gastric cancer. The levels of ULBP1 and NKG2D expression were examined in human gastric cancer cell lines and gastric cancer tissues from 98 patients who underwent surgery from 2004 to 2008. MKN‑74 cells expressed ULBP1 with ULBP2, ‑5, or ‑6. NKG2D was expressed at a higher level following activation of T cells and NK cells. Among the tissue sections positive for NKG2D expression, 6 patients were positive for CD8 and CD56. In all tissues, NKG2D‑expressing cells were typically aCD8+ T cells. Patients with NKG2D expression in tumors exhibited significantly longer overall survival (OS) compared with patients without NKG2D expression in tumors (P=0.0217). The longest OS was observed in patients positive for ULBP1 and NKG2D, whereas the shortest OS was observed in patients negative for ULBP1 and NKG2D. The interaction between ULBP1 and NKG2D may improve OS in patients with gastric cancer, and may have applications in immunotherapy for the induction of adaptive immunity in patients with cancer. Additionally, ULBP1 and NKG2D may be useful as prognostic biomarkers in gastric cancer.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Kamei, R., Yoshimura, K., Yoshino, S., Inoue, M., Asao, T., Fuse, M. ... Nagano, H. (2018). Expression levels of UL16 binding protein 1 and natural killer group 2 member D affect overall survival in patients with gastric cancer following gastrectomy. Oncology Letters, 15, 747-754. https://doi.org/10.3892/ol.2017.7354
MLA
Kamei, R., Yoshimura, K., Yoshino, S., Inoue, M., Asao, T., Fuse, M., Wada, S., Kuramasu, A., Furuya‑Kondo, T., Oga, A., Iizuka, N., Suzuki, N., Maeda, N., Watanabe, Y., Matsukuma, S., Iida, M., Takeda, S., Ueno, T., Yamamoto, N., Fukagawa, T., Katai, H., Sasaki, H., Hazama, S., Oka, M., Nagano, H."Expression levels of UL16 binding protein 1 and natural killer group 2 member D affect overall survival in patients with gastric cancer following gastrectomy". Oncology Letters 15.1 (2018): 747-754.
Chicago
Kamei, R., Yoshimura, K., Yoshino, S., Inoue, M., Asao, T., Fuse, M., Wada, S., Kuramasu, A., Furuya‑Kondo, T., Oga, A., Iizuka, N., Suzuki, N., Maeda, N., Watanabe, Y., Matsukuma, S., Iida, M., Takeda, S., Ueno, T., Yamamoto, N., Fukagawa, T., Katai, H., Sasaki, H., Hazama, S., Oka, M., Nagano, H."Expression levels of UL16 binding protein 1 and natural killer group 2 member D affect overall survival in patients with gastric cancer following gastrectomy". Oncology Letters 15, no. 1 (2018): 747-754. https://doi.org/10.3892/ol.2017.7354