Open Access

High secreted protein acidic and rich in cysteine expression in peritumoral fibroblasts predicts better prognosis in patients with resectable gastric cancer

  • Authors:
    • Masao Nakajima
    • Shigefumi Yoshino
    • Shinsuke Kanekiyo
    • Noriko Maeda
    • Kazuhiko Sakamoto
    • Ryoichi Tsunedomi
    • Nobuaki Suzuki
    • Shigeru Takeda
    • Shigeru Yamamoto
    • Shoichi Hazama
    • Yoshinobu Hoshii
    • Atsunori Oga
    • Hiroshi Itoh
    • Tomio Ueno
    • Hiroaki Nagano
  • View Affiliations

  • Published online on: November 15, 2017     https://doi.org/10.3892/ol.2017.7418
  • Pages:803-812
  • Copyright: © Nakajima et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Secreted protein acidic and rich in cysteine (SPARC) is an extracellular matrix glycoprotein that may serve an important role in epithelial‑mesenchymal transition. Recent studies have demonstrated that SPARC status is a prognostic indicator in various cancer types; however, its value remains unclear in gastric cancer (GC). In the present study, the localization and prognostic impact of SPARC expression were evaluated in patients with GC. Immunohistochemical analysis of SPARC expression was performed in 117 surgically resected GC specimens, and the localization of SPARC positive cells, as well as the rassociation between SPARC expression and clinicopathological characteristics were evaluated. High SPARC expression was observed in 47 cases; the glycoprotein was localized in the peritumoral fibroblasts, but was rarely observed in the cytoplasm of cancer cells. Heterogeneity of SPARC expression was observed in 52 cases. High stromal SPARC expression was identified to be an independent predictor of more favorable prognosis (overall survival and recurrence free survival) in all patients (P<0.001). On subgroup analysis, this association remained significant in patients who received adjuvant chemotherapy, but not in patients who did not (P<0.001). Stromal SPARC expression predicts better prognosis in GC patients who underwent curative resection; this appears to be associated with improved response to chemotherapy.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Nakajima, M., Yoshino, S., Kanekiyo, S., Maeda, N., Sakamoto, K., Tsunedomi, R. ... Nagano, H. (2018). High secreted protein acidic and rich in cysteine expression in peritumoral fibroblasts predicts better prognosis in patients with resectable gastric cancer. Oncology Letters, 15, 803-812. https://doi.org/10.3892/ol.2017.7418
MLA
Nakajima, M., Yoshino, S., Kanekiyo, S., Maeda, N., Sakamoto, K., Tsunedomi, R., Suzuki, N., Takeda, S., Yamamoto, S., Hazama, S., Hoshii, Y., Oga, A., Itoh, H., Ueno, T., Nagano, H."High secreted protein acidic and rich in cysteine expression in peritumoral fibroblasts predicts better prognosis in patients with resectable gastric cancer". Oncology Letters 15.1 (2018): 803-812.
Chicago
Nakajima, M., Yoshino, S., Kanekiyo, S., Maeda, N., Sakamoto, K., Tsunedomi, R., Suzuki, N., Takeda, S., Yamamoto, S., Hazama, S., Hoshii, Y., Oga, A., Itoh, H., Ueno, T., Nagano, H."High secreted protein acidic and rich in cysteine expression in peritumoral fibroblasts predicts better prognosis in patients with resectable gastric cancer". Oncology Letters 15, no. 1 (2018): 803-812. https://doi.org/10.3892/ol.2017.7418