Open Access

Perfused hypertonic-saline-augmented needle enlarges ablation zones in ex vivo porcine livers

  • Authors:
    • Caoye Wang
    • Qi Wang
    • Dachuan Zhang
    • Zhongming He
    • Wenhua Chen
  • View Affiliations

  • Published online on: November 6, 2017     https://doi.org/10.3892/ol.2017.7352
  • Pages:972-978
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There is a great clinical requirement to improve radiofrequency ablation (RFA) efficacy and create larger coagulation necrotic areas. The aim of the present study was to assess the ability of a hypertonic‑saline (HS)‑enhanced multipolar RFA technique using a perfused electrode to increase RF‑created coagulation necrosis, and to compare that technique with natural saline‑augmented needle and conventional multipolar RFA. A total of 18 ablations were performed in explanted porcine livers. A total of 6 thermal ablation zones were created in each of 3 groups treated with the conventional multipolar mode, the multipolar mode with 0.9% NaCl and the multipolar mode with 6% NaCl, respectively. During RFA, the dimensions and volumes of the ablation zones were compared, and gross and microscopic pathological evaluations were performed. Multipolar RFA with 6% NaCl created the largest short‑axis diameters and volumes of coagulation necrosis (3.89±0.09 mm and 40.01±2.86 mm3, respectively) among the three groups (conventional group: 2.31±0.04 mm and 8.99±0.52 mm3, respectively; 0.9% NaCl solution group: 3.17±0.05 mm and 21.79±1.05 mm3, respectively). Overall, multipolar RFA with the instillation of 6% NaCl solution through an open perfusion system created a larger ablation zone compared with the conventional and 0.9% NaCl modes. Therefore, HS‑enhanced multipolar RFA may be a promising approach for treating large liver tumors.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Wang, C., Wang, Q., Zhang, D., He, Z., & Chen, W. (2018). Perfused hypertonic-saline-augmented needle enlarges ablation zones in ex vivo porcine livers. Oncology Letters, 15, 972-978. https://doi.org/10.3892/ol.2017.7352
MLA
Wang, C., Wang, Q., Zhang, D., He, Z., Chen, W."Perfused hypertonic-saline-augmented needle enlarges ablation zones in ex vivo porcine livers". Oncology Letters 15.1 (2018): 972-978.
Chicago
Wang, C., Wang, Q., Zhang, D., He, Z., Chen, W."Perfused hypertonic-saline-augmented needle enlarges ablation zones in ex vivo porcine livers". Oncology Letters 15, no. 1 (2018): 972-978. https://doi.org/10.3892/ol.2017.7352