Pituitary tumor‑transforming 1 expression in laryngeal cancer and its association with prognosis

  • Authors:
    • Kunpeng Ma
    • Limin Ma
    • Zhaocheng Jian
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  • Published online on: May 18, 2018     https://doi.org/10.3892/ol.2018.8745
  • Pages: 1107-1114
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Abstract

The purpose of the present study was to investigate the association between the expression of pituitary tumor‑transforming 1 (PTTG1) and the expression of matrix metalloproteinase (MMP)‑2 and MMP‑9 in laryngeal carcinoma tissues, and to elucidate the association between PTTG1 expression and the prognosis of patients with laryngeal cancer. Immunohistochemical staining was used to detect PTTG1 expression in laryngeal cancer and normal tumor‑adjacent laryngeal tissues. Western blotting was used to determine the levels of PTTG1 and MMP‑2 and ‑9 in laryngeal carcinoma tissues and to assess their correlation. In addition, the associations between PTTG1 expression and the clinical parameters of laryngeal cancer and patient survival were determined. The immunohistochemistry results revealed that the positive expression rates of PTTG1, MMP‑2 and MMP‑9 in the laryngeal cancer tissues were significantly higher than those in the carcinoma‑adjacent normal laryngeal tissues (all P<0.05). In addition, expression levels of PTTG1, MMP‑2 and MMP‑9 were significantly associated with lymph node metastasis, histological grade and clinical stage (P<0.05). Furthermore, the levels of PTTG1 were positively correlated with the levels of MMP‑2 and MMP‑9 in laryngeal cancer tissues (P<0.05). In summary, the expression levels of PTTG1, MMP‑2 and MMP‑9 are closely associated with the biological behaviors of laryngeal cancer tissues, showing that they serve important roles in the occurrence and development of laryngeal cancer, and may be useful as biological indicators of laryngeal tissue invasion, metastasis and patient prognosis.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ma K, Ma L and Jian Z: Pituitary tumor‑transforming 1 expression in laryngeal cancer and its association with prognosis. Oncol Lett 16: 1107-1114, 2018.
APA
Ma, K., Ma, L., & Jian, Z. (2018). Pituitary tumor‑transforming 1 expression in laryngeal cancer and its association with prognosis. Oncology Letters, 16, 1107-1114. https://doi.org/10.3892/ol.2018.8745
MLA
Ma, K., Ma, L., Jian, Z."Pituitary tumor‑transforming 1 expression in laryngeal cancer and its association with prognosis". Oncology Letters 16.1 (2018): 1107-1114.
Chicago
Ma, K., Ma, L., Jian, Z."Pituitary tumor‑transforming 1 expression in laryngeal cancer and its association with prognosis". Oncology Letters 16, no. 1 (2018): 1107-1114. https://doi.org/10.3892/ol.2018.8745