EZH2 inhibition promotes methyl jasmonate‑induced apoptosis of human colorectal cancer through the Wnt/β‑catenin pathway

Retraction in: /10.3892/ol.2021.12832

  • Authors:
    • Yao Wang
    • Li Fan
    • Chunguo Cui
    • Yongkun Wang
    • Tingting Liang
  • View Affiliations

  • Published online on: May 22, 2018     https://doi.org/10.3892/ol.2018.8779
  • Pages: 1231-1236
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Abstract

Methyl jasmonate potentially induces the differentiation of human myeloid leukemia cells and inhibits their proliferation; it may induce the differentiation and apoptosis of human lymphocytic leukemia cells, but does not exert a damaging effect on normal lymphocytes. In the present study, the anticancer effect of methyl jasmonate on human colorectal cancer cells was investigated. Cell viability and apoptosis was assessed using a Cell Counting kit‑8 assay and flow cytometry, respectively. Methyl jasmonate suppressed cell viability and induced apoptosis in human colorectal cancer cells. Additionally, methyl jasmonate increased the activation of caspase‑3, inhibited the expression levels of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and the Wnt/β‑catenin pathway in human colorectal cancer. Downregulation of EZH2 expression enhanced the anticancer effect of methyl jasmonate on human colorectal cancer cells through suppression of the Wnt/β‑catenin pathway. Thus, EZH2 downregulation promotes the anticancer effect of methyl jasmonate by inducing apoptosis in human colorectal cancer cells through the Wnt/β‑catenin pathway.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang Y, Fan L, Cui C, Wang Y and Liang T: EZH2 inhibition promotes methyl jasmonate‑induced apoptosis of human colorectal cancer through the Wnt/β‑catenin pathway Retraction in /10.3892/ol.2021.12832. Oncol Lett 16: 1231-1236, 2018
APA
Wang, Y., Fan, L., Cui, C., Wang, Y., & Liang, T. (2018). EZH2 inhibition promotes methyl jasmonate‑induced apoptosis of human colorectal cancer through the Wnt/β‑catenin pathway Retraction in /10.3892/ol.2021.12832. Oncology Letters, 16, 1231-1236. https://doi.org/10.3892/ol.2018.8779
MLA
Wang, Y., Fan, L., Cui, C., Wang, Y., Liang, T."EZH2 inhibition promotes methyl jasmonate‑induced apoptosis of human colorectal cancer through the Wnt/β‑catenin pathway Retraction in /10.3892/ol.2021.12832". Oncology Letters 16.1 (2018): 1231-1236.
Chicago
Wang, Y., Fan, L., Cui, C., Wang, Y., Liang, T."EZH2 inhibition promotes methyl jasmonate‑induced apoptosis of human colorectal cancer through the Wnt/β‑catenin pathway Retraction in /10.3892/ol.2021.12832". Oncology Letters 16, no. 1 (2018): 1231-1236. https://doi.org/10.3892/ol.2018.8779