Correlation of SOCS‑1 gene with onset and prognosis of breast cancer

Lv,Yuetao; Song,Ge; Li,Peng

doi:10.3892/ol.2018.8675

Correlation of SOCS‑1 gene with onset and prognosis of breast cancer

Authors:
- Yuetao Lv
- Ge Song
- Peng Li
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Affiliations: Department of Breast and Thyroid Surgery, Jining First People's Hospital, Jining, Shandong 272000, P.R. China, Department of Health Management, Jining First People's Hospital, Jining, Shandong 272000, P.R. China
Published online on: May 9, 2018 https://doi.org/10.3892/ol.2018.8675
Pages: 383-387

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Abstract

The aim of the present study is to study the expressions of suppressor of cytokine signaling (SOCS)‑1 in the tumor tissues and adjacent normal tissues of patients with breast cancer. The study was also planned to investigate the association of SOCS‑1 gene expression with patients' clinical pathology, molecular subtype and prognosis. A total of 60 cases of frozen and paraffin‑embedded specimens of tumor tissues and corresponding adjacent normal tissues of patients with breast cancer were selected. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression levels of SOCS‑1 messenger RNA (mRNA) in the patients' tumor tissues and adjacent normal tissues. The immunohistochemical method was applied to detect the expressions of SOCS‑1 proteins in the patients' breast cancer tissues and adjacent normal tissues. Moreover, the correlations of SOCS‑1 protein expressions in breast cancer tissues with patients' pathological parameters, molecular subtypes and prognosis were analyzed in combination with the clinical data. The results of RT-qPCR showed that the SOCS‑1 mRNA expression in breast cancer tissues was significantly lower than that in adjacent normal tissues (p<0.01). The immunohistochemical results indicated that the positive expression rate of the SOCS‑1 proteins in breast cancer tissues (23.33%) was remarkably lower than that in adjacent normal tissues (88.33%) (p<0.01). The low expression of SOCS‑1 in breast cancer tissues was related to lymph node metastasis and clinical staging. The positive expression rates of the luminal A SOCS‑1 proteins were the highest (47.62%) (p<0.01). The 5‑year overall survival rate of the breast cancer patients was 63.33% (38/60). The univariate survival analysis revealed that the patients with low expression of SOCS‑1 had poorer prognosis. In conclusion, the low expression of SOCS‑1 plays a key role in the pathogenesis of breast cancer; in particular, it is associated with the lymph node metastasis and clinical staging of the tumor; so, the SOCS‑1 expression in breast cancer tissues can be regarded as an important reference for the prognostic estimation of breast cancer.

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