Open Access

Long noncoding RNA UPAT promoted cell proliferation via increasing UHRF1 expression in non‑small cell lung cancer

  • Authors:
    • Haiqin Wang
    • Dakui Cao
    • Fengjie Wu
  • View Affiliations

  • Published online on: May 30, 2018     https://doi.org/10.3892/ol.2018.8829
  • Pages: 1491-1498
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Evidence indicates that long non‑coding RNAs (lncRNAs) serve a critical role in the regulation of non‑small cell lung cancer (NSCLC) progression. LncRNA Ubiquitin‑like with PHD and RING finger domains 1 (UHRF1) protein associated transcript (UPAT) has been identified to be overexpressed in a variety of types of cancer. The present study demonstrated that lncRNA UPAT expression was upregulated in NSCLC tissues and significantly associated with tumor size and Tumor‑Node‑Metastasis stage. Additionally, UPAT promoted NSCLC cell proliferation and G1‑S phase transition in vitro. Furthermore, UPAT promoted NSCLC cell proliferation, partly via increasing UHRF1 expression and consequently epigenetically silencing RASSF1 and CDH13 transcription. In addition, the knockdown of UHRF1 partially decreased the promotion of cell growth and G1‑S phase transition caused by UPAT overexpression. In conclusion, these data suggest that the lncRNA UPAT promotes the NSCLC cell proliferation and may be a potential therapeutic target of NSCLC.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang H, Cao D and Wu F: Long noncoding RNA UPAT promoted cell proliferation via increasing UHRF1 expression in non‑small cell lung cancer. Oncol Lett 16: 1491-1498, 2018
APA
Wang, H., Cao, D., & Wu, F. (2018). Long noncoding RNA UPAT promoted cell proliferation via increasing UHRF1 expression in non‑small cell lung cancer. Oncology Letters, 16, 1491-1498. https://doi.org/10.3892/ol.2018.8829
MLA
Wang, H., Cao, D., Wu, F."Long noncoding RNA UPAT promoted cell proliferation via increasing UHRF1 expression in non‑small cell lung cancer". Oncology Letters 16.2 (2018): 1491-1498.
Chicago
Wang, H., Cao, D., Wu, F."Long noncoding RNA UPAT promoted cell proliferation via increasing UHRF1 expression in non‑small cell lung cancer". Oncology Letters 16, no. 2 (2018): 1491-1498. https://doi.org/10.3892/ol.2018.8829