Open Access

Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer

  • Authors:
    • Tian‑Ming Zhang
    • Tao Huang
    • Rong‑Fei Wang
  • View Affiliations

  • Published online on: May 31, 2018     https://doi.org/10.3892/ol.2018.8860
  • Pages: 1736-1746
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer is a severe cancer associated with a high prevalence and fatality rate. There are three major mechanisms for colorectal cancer: (1) Chromosome instability (CIN), (2) CpG island methylator phenotype (CIMP) and (3) mismatch repair (MMR), of which CIN is the most common type. However, these subtypes are not exclusive and overlap. To investigate their biological mechanisms and cross talk, the gene expression profiles of 585 colorectal cancer patients with CIN, CIMP and MMR status records were collected. By comparing the CIN+ and CIN‑ samples, CIMP+ and CIMP‑ samples, MMR+ and MMR‑ samples with minimal redundancy maximal relevance (mRMR) and incremental feature selection (IFS) methods, the CIN, CIMP and MMR associated genes were selected. Unfortunately, there was little direct overlap among them. To investigate their indirect interactions, downstream genes of CIN, CIMP and MMR were identified using the random walk with restart (RWR) method and a greater overlap of downstream genes was indicated. The common downstream genes were involved in biosynthetic and metabolic pathways. These findings were consistent with the clinical observation of wide range metabolite aberrations in colorectal cancer. To conclude, the present study gave a gene level explanation of CIN, CIMP and MMR, but also showed the network level cross talk of CIN, CIMP and MMR. The common genes of CIN, CIMP and MMR may be useful for cross‑subtype general colorectal cancer drug development.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang TM, Huang T and Wang RF: Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer. Oncol Lett 16: 1736-1746, 2018
APA
Zhang, T., Huang, T., & Wang, R. (2018). Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer. Oncology Letters, 16, 1736-1746. https://doi.org/10.3892/ol.2018.8860
MLA
Zhang, T., Huang, T., Wang, R."Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer". Oncology Letters 16.2 (2018): 1736-1746.
Chicago
Zhang, T., Huang, T., Wang, R."Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer". Oncology Letters 16, no. 2 (2018): 1736-1746. https://doi.org/10.3892/ol.2018.8860