Open Access

High MMP‑26 expression in glioma is correlated with poor clinical outcome of patients

  • Authors:
    • Jian‑Gui Guo
    • Cheng‑Cheng Guo
    • Zhen‑Qiang He
    • Xiu‑Yu Cai
    • Yong‑Gao Mou
  • View Affiliations

  • Published online on: June 4, 2018     https://doi.org/10.3892/ol.2018.8880
  • Pages: 2237-2242
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

To date the management of glioma remains a great challenge in cancer therapy worldwide. The identification of novel diagnostic and therapeutic methods is required. Although there is data indicating that matrix metalloproteinase (MMP)‑26 serves an important role in many human cancer types, its clinical significance in glioma remains uncertain. The present study aimed to evaluate MMP‑26 expression in human astrocytic glioma specimens, and investigate its role and significance in the progression of astrocytic glioma. Immunohistochemistry was performed to assess MMP‑26 expression in astrocytic glioma tissues. The levels of MMP‑26 expression and its relevance to the clinicopathological features and prognostic factors in patients with astrocytic glioma patients were then investigated. The results demonstrated that MMP‑26 expression was significantly assocaited with the World Health Organization grade (P<0.05). Additionally, it was identified that MMP‑26 expression was an effective predictor of the overall survival of patients with astrocytic glioma (P<0.05). Analyses of univariate and multivariate Cox regression confirmed that MMP‑26 expression was an independent factor for evaluating the prognosis of astrocytic glioma patients (P<0.05). The current results support that MMP‑26 may be a novel indicator of diagnosis and an independent factor for evaluating prognosis in patients with glioma.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Guo JG, Guo CC, He ZQ, Cai XY and Mou YG: High MMP‑26 expression in glioma is correlated with poor clinical outcome of patients. Oncol Lett 16: 2237-2242, 2018
APA
Guo, J., Guo, C., He, Z., Cai, X., & Mou, Y. (2018). High MMP‑26 expression in glioma is correlated with poor clinical outcome of patients. Oncology Letters, 16, 2237-2242. https://doi.org/10.3892/ol.2018.8880
MLA
Guo, J., Guo, C., He, Z., Cai, X., Mou, Y."High MMP‑26 expression in glioma is correlated with poor clinical outcome of patients". Oncology Letters 16.2 (2018): 2237-2242.
Chicago
Guo, J., Guo, C., He, Z., Cai, X., Mou, Y."High MMP‑26 expression in glioma is correlated with poor clinical outcome of patients". Oncology Letters 16, no. 2 (2018): 2237-2242. https://doi.org/10.3892/ol.2018.8880