A case of groans, moans and stones with malignant undertones: Endometrioid carcinoma-associated hypercalcemia

Visnyei,Koppany; Shahrokni,Armin; Hashmi,Shahrukh; Orell,Jeffrey; Wild,Dorothea  M.G.

doi:10.3892/ol.2011.475

A case of groans, moans and stones with malignant undertones: Endometrioid carcinoma-associated hypercalcemia

Authors:
- Koppany Visnyei
- Armin Shahrokni
- Shahrukh Hashmi
- Jeffrey Orell
- Dorothea M.G. Wild
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Affiliations: Department of Medicine, Griffin Hospital, Derby, CT 06401, USA, Department of Geriatric Oncology at the University of California, Los Angeles, CA, USA, James P. Wilmot Cancer Center, University of Rochester, NY, USA, Center for Cancer Care, Griffin Hospital, Yale School of Medicine, Derby, CT, USA
Published online on: November 8, 2011 https://doi.org/10.3892/ol.2011.475
Pages: 335-337

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Abstract

Humoral hypercalcemia of malignancy is frequently observed in patients with solid tumors. However, few instances have been described involving patients with gynecological malignancies. We report a case of endometrioid carcinoma of the uterine corpus in a patient who initially presented with hypercalcemia. The elevated calcium levels were found to be the result of an increased serum concentration of parathyroid hormone-related peptide (PTHrP). PTHrP is commonly secreted by malignant cells and suppresses PTH. This case demonstrates that endometrial cancer should be considered in the differential diagnosis of patients presenting with symptomatic or asymptomatic hypercalcemia.

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