α‑smooth muscle actin‑positive fibroblasts correlate with poor survival in hepatocellular carcinoma
- Authors:
- Jignesh G. Parikh
- Anand Kulkarni
- Cameila Johns
View Affiliations
Affiliations: Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
- Published online on: November 29, 2013 https://doi.org/10.3892/ol.2013.1720
-
Pages:
573-575
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Abstract
The current case‑control study was conducted to assess the value of activated fibroblasts with high α‑smooth muscle actin (α‑SMA) expression as an indicator of survival in hepatocellular carcinoma (HCC) patients. In total, 47 patients diagnosed with HCC who underwent a liver biopsy at the Veterans Affairs Medical Center (Memphis, TN, USA) between January 2000 and December 2009, and 10 age‑ and gender‑matched controls with normal liver biopsy samples were included in the study. The immunohistochemical staining for α‑SMA was performed and classified qualitatively and quantitatively within tumor stroma and perisinusoidal spaces. HCC patients with high qualitative and quantitative expression of α‑SMA revealed a statistically significant negative correlation with 3‑year [odds ratio (OR), 0.021 and 0.111; P=0.001 and 0.0302, respectively] and 1.5‑year (OR, 0.040 and 0.051; P=0.0330 and 0.0492, respectively) survival rates in comparison with low expression. The results of the present study demonstrated a predictive role of high qualitative and quantitative expression in activated fibroblasts for poor survival in patients with HCC.
View References
|
1
|
Micke P and Ostman A: Exploring the tumor
environment: cancer-associated fibroblasts as targets in cancer
therapy. Expert Opin Ther Targets. 9:1217–1233. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Olumi AF, Grossfeld GD, Hayward SW, et al:
Carcinoma-associated fibroblasts direct tumor progression of
initiated human prostatic epithelium. Cancer Res. 59:5002–5011.
1999.
|
|
3
|
Chuaysri C, Thuwajit P, Paupairoj A, et
al: Alpha-smooth muscle actin-positive fibroblasts promote biliary
cell proliferation and correlate with poor survival in
cholangiocarcinoma. Oncol Rep. 21:957–969. 2009.
|
|
4
|
Kuang P, Zhao W, Su W, et al:
18β-glycyrrhetinic acid inhibits hepatocellular carcinoma
development by reversing hepatic stellate cell-mediated
immunosuppression in mice. Int J Cancer. 132:1831–1841. 2013.
|
|
5
|
Hautekeete ML and Geerts A: The hepatic
stellate (Ito) cell: its role in human liver disease. Virchows
Arch. 430:195–207. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Carpino G, Morini S, Ginanni CS, et al:
Alpha-SMA expression in hepatic stellate cells and quantitative
analysis of hepatic fibrosis in cirrhosis and in recurrent chronic
hepatitis after liver transplantation. Dig Liver Dis. 37:349–356.
2005. View Article : Google Scholar
|
|
7
|
Desmoulière A, Guyot C and Gabbiani G: The
stroma reaction myofibroblast: a key player in the control of tumor
cell behavior. Int J Dev Biol. 48:509–517. 2004.PubMed/NCBI
|
|
8
|
Friedman SL: Mechanism of hepatic
fibrogenesis. Gastroenterology. 134:1655–1669. 2008. View Article : Google Scholar
|
|
9
|
Desmet VJ and Rosai J: Liver: tumors and
tumorlike conditions. Rosai and Akerman’s Surgical Pathology. Rosai
J: 10th Edition. Mosby Elsevier; New York: pp. 944–953. 2011
|
|
10
|
Bruix J and Sherman M; American
Association for the Study of Liver Diseases. Management of
hepatocellular carcinoma: an update. Hepatology. 53:1020–1022.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Yu MC, Chen CH, Liang X, et al: Inhibition
of T-cell responses by hepatic stellate cells via B7-H1-mediated
T-cell apoptosis in mice. Hepatology. 40:1312–1321. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Chen CH, Kuo LM, Chang Y, et al: In vivo
immune modulatory activity of hepatic stellate cells in mice.
Hepatology. 44:1171–1181. 2006. View Article : Google Scholar : PubMed/NCBI
|
