Natural history of recurrences in endometrial carcinoma

  • Authors:
    • Bengt Sorbe
    • Christian Juresta
    • Cecilia Ahlin
  • View Affiliations

  • Published online on: July 18, 2014     https://doi.org/10.3892/ol.2014.2362
  • Pages: 1800-1806
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to evaluate the natural history of endometrial cancer recurrences with regard to predictive and prognostic factors. Between 1990 and 1999, 100 patients were treated for recurrences of endometrial carcinoma (all FIGO stages). Overall, 90 tumors were of endometrioid type. A total of 82 patients were treated with surgery, 41 patients received adjuvant external irradiation and 91 patients received vaginal brachytherapy. The median time to recurrence (TTR) was 32 months. The recurrences were treated using a combination of high‑dose‑rate brachytherapy and external pelvic irradiation in 35 cases. In addition, 44 patients were treated with chemotherapy and 21 patients received other types of therapy. The complete remission rate was 29% and the overall response rate was 44%. Among patients treated with radiotherapy, the response rate was 88% and, for those treated with chemotherapy, the rate was 33%. The local control of vaginal recurrences treated with combined radiotherapy was 93%. In 45 patients (45%) a second recurrence was identified and a third recurrence occurred in 12 patients. The overall five‑year survival rate was 44%. Age, FIGO grade, nuclear grade, TTR and response to treatment were found to be independent and significant prognostic factors for overall survival rate. Locoregional recurrences were associated with a generalized extra‑pelvic disease in 63% of the cases.
View Figures
View References

Related Articles

Journal Cover

October 2014
Volume 8 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sorbe B, Juresta C and Ahlin C: Natural history of recurrences in endometrial carcinoma. Oncol Lett 8: 1800-1806, 2014
APA
Sorbe, B., Juresta, C., & Ahlin, C. (2014). Natural history of recurrences in endometrial carcinoma. Oncology Letters, 8, 1800-1806. https://doi.org/10.3892/ol.2014.2362
MLA
Sorbe, B., Juresta, C., Ahlin, C."Natural history of recurrences in endometrial carcinoma". Oncology Letters 8.4 (2014): 1800-1806.
Chicago
Sorbe, B., Juresta, C., Ahlin, C."Natural history of recurrences in endometrial carcinoma". Oncology Letters 8, no. 4 (2014): 1800-1806. https://doi.org/10.3892/ol.2014.2362