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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November-December 2003 Volume 10 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Paclitaxel and liposomal doxorubicin (Caelyx) combination in advanced breast cancer patients: a Phase II study

  • Authors:
    • Sotiris K. Rigatos
    • Dimitrios Tsavdaridis
    • Athanasios Athanasiadis
    • John G. Stathopoulos
    • George P. Stathopoulos

  • View Affiliations / Copyright

    Affiliations: Oncology Department, Errikos Dynan Hospital, Athens, Greece
  • Pages: 1817-1819
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/or.10.6.1817
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Abstract

Due to the cumulative cardiotoxicity of doxorubicin in cancer treatment, the tendency of the physician to find a substitute has led to the use of liposomal encapsulated doxorubicin, as well as other similar compounds. Doxorubicin and paclitaxel, two of the most active agents for breast cancer, have often been used in combination for this condition. In the present study we combined liposomal doxorubicin with paclitaxel with the intention of diminishing the toxicity of the cardiac muscle. Twenty-three patients were evaluated for response rate, survival and toxicity. All patients had metastatic disease and were chemotherapy-naïve after generalization of the disease. Liposomal doxorubicin was infused at a dose of 30 mg/m2 and paclitaxel at a dose of 175 mg/m2 once every 3 weeks. The response rate was complete in 2 patients (8.70%) and partial in 14 patients (60.87%) totalling 69.57%. The median duration of response was 6 months (range 2-13+) and median survival was 10 months (range 4-20+). Cardiotoxicity, myelotoxicity and gastrointestinal toxicity were well-tolerated. The high hand-foot adverse reaction (47.83%) inhibited the continuation of treatment in half of the patients and due to this toxicity the trial was terminated after the 23rd patient.

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Copy and paste a formatted citation
Spandidos Publications style
Rigatos SK, Tsavdaridis D, Athanasiadis A, Stathopoulos JG and Stathopoulos GP: Paclitaxel and liposomal doxorubicin (Caelyx) combination in advanced breast cancer patients: a Phase II study. Oncol Rep 10: 1817-1819, 2003.
APA
Rigatos, S.K., Tsavdaridis, D., Athanasiadis, A., Stathopoulos, J.G., & Stathopoulos, G.P. (2003). Paclitaxel and liposomal doxorubicin (Caelyx) combination in advanced breast cancer patients: a Phase II study. Oncology Reports, 10, 1817-1819. https://doi.org/10.3892/or.10.6.1817
MLA
Rigatos, S. K., Tsavdaridis, D., Athanasiadis, A., Stathopoulos, J. G., Stathopoulos, G. P."Paclitaxel and liposomal doxorubicin (Caelyx) combination in advanced breast cancer patients: a Phase II study". Oncology Reports 10.6 (2003): 1817-1819.
Chicago
Rigatos, S. K., Tsavdaridis, D., Athanasiadis, A., Stathopoulos, J. G., Stathopoulos, G. P."Paclitaxel and liposomal doxorubicin (Caelyx) combination in advanced breast cancer patients: a Phase II study". Oncology Reports 10, no. 6 (2003): 1817-1819. https://doi.org/10.3892/or.10.6.1817
Copy and paste a formatted citation
x
Spandidos Publications style
Rigatos SK, Tsavdaridis D, Athanasiadis A, Stathopoulos JG and Stathopoulos GP: Paclitaxel and liposomal doxorubicin (Caelyx) combination in advanced breast cancer patients: a Phase II study. Oncol Rep 10: 1817-1819, 2003.
APA
Rigatos, S.K., Tsavdaridis, D., Athanasiadis, A., Stathopoulos, J.G., & Stathopoulos, G.P. (2003). Paclitaxel and liposomal doxorubicin (Caelyx) combination in advanced breast cancer patients: a Phase II study. Oncology Reports, 10, 1817-1819. https://doi.org/10.3892/or.10.6.1817
MLA
Rigatos, S. K., Tsavdaridis, D., Athanasiadis, A., Stathopoulos, J. G., Stathopoulos, G. P."Paclitaxel and liposomal doxorubicin (Caelyx) combination in advanced breast cancer patients: a Phase II study". Oncology Reports 10.6 (2003): 1817-1819.
Chicago
Rigatos, S. K., Tsavdaridis, D., Athanasiadis, A., Stathopoulos, J. G., Stathopoulos, G. P."Paclitaxel and liposomal doxorubicin (Caelyx) combination in advanced breast cancer patients: a Phase II study". Oncology Reports 10, no. 6 (2003): 1817-1819. https://doi.org/10.3892/or.10.6.1817
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