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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November-December 2003 Volume 10 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November-December 2003 Volume 10 Issue 6

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Article

In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells

  • Authors:
    • X. Steven Wan
    • Zhoazong Zhou
    • Ann R. Kennedy
    • Levy Kopelovich

  • View Affiliations / Copyright

    Affiliations: University of Pennsylvania, Philadelphia, PA 19104-6072, USA. xswan@mail.med.upenn.edu
  • Pages: 2009-2014
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/or.10.6.2009
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Abstract

The effects of nine potential cancer chemopreventive agents on cell growth or clonogenic survival were evaluated in normal human prostate epithelial cells, an immortalized but non-tumorigenic human prostate epithelial cell line (267B1), a human benign prostatic hyperplasia (BPH) cell line (BRF-55T), and a human prostate cancer cell line (267B1/Ki-ras). Of the nine agents tested, 9-cis retinoic acid, liarozole fumarate, phenylenebis(methylene)-selenocyanate (p-XSC), and L-selenomethionine demonstrated much stronger growth inhibitory effects on prostate cancer cells than on the normal prostate epithelial cells, suggesting that these agents may be useful as prostate cancer chemopreventive agents. 9-cis retinoic acid, genistein, liarozole fumarate, p-XSC, L-selenomethionine and vitamin E also showed much stronger growth inhibitory effects on BRF-55T cells than on the normal prostate epithelial cells, indicating that these agents may also be useful for the prevention and treatment of BPH. Difluoromethylornithine (DFMO), DHEA analogue 8354 (fluasterone), and oltipraz did not show strong inhibitory effects on the growth or survival of normal prostate epithelial cells, 267B1 or 267B1/Ki-ras cells, suggesting that these agents may not be effective as prostate cancer preventive or therapeutic agents.

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Copy and paste a formatted citation
Spandidos Publications style
Wan XS, Zhou Z, Kennedy AR and Kopelovich L: In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells. Oncol Rep 10: 2009-2014, 2003.
APA
Wan, X.S., Zhou, Z., Kennedy, A.R., & Kopelovich, L. (2003). In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells. Oncology Reports, 10, 2009-2014. https://doi.org/10.3892/or.10.6.2009
MLA
Wan, X. S., Zhou, Z., Kennedy, A. R., Kopelovich, L."In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells". Oncology Reports 10.6 (2003): 2009-2014.
Chicago
Wan, X. S., Zhou, Z., Kennedy, A. R., Kopelovich, L."In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells". Oncology Reports 10, no. 6 (2003): 2009-2014. https://doi.org/10.3892/or.10.6.2009
Copy and paste a formatted citation
x
Spandidos Publications style
Wan XS, Zhou Z, Kennedy AR and Kopelovich L: In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells. Oncol Rep 10: 2009-2014, 2003.
APA
Wan, X.S., Zhou, Z., Kennedy, A.R., & Kopelovich, L. (2003). In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells. Oncology Reports, 10, 2009-2014. https://doi.org/10.3892/or.10.6.2009
MLA
Wan, X. S., Zhou, Z., Kennedy, A. R., Kopelovich, L."In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells". Oncology Reports 10.6 (2003): 2009-2014.
Chicago
Wan, X. S., Zhou, Z., Kennedy, A. R., Kopelovich, L."In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells". Oncology Reports 10, no. 6 (2003): 2009-2014. https://doi.org/10.3892/or.10.6.2009
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