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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2007 Volume 17 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo

  • Authors:
    • E. Ako
    • Y. Yamashita
    • M. Ohira
    • M. Yamazaki
    • T. Hori
    • N. Kubo
    • T. Sawada
    • K. Hirakawa

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan
  • Pages: 887-893
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/or.17.4.887
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Abstract

The epidermal growth factor receptor (EGFR) is a member of the EGFR family of receptors. EGFR and other members of the EGFR family have been shown to play significant roles in human cancer cell proliferation and therefore present important molecular targets for the treatment of cancer. The purpose of this study was to examine the effect of the pan-erbB tyrosine kinase inhibitor CI-1033 against esophageal squamous cell carcinoma in vitro and in vivo. We selected 4 human esophageal squamous cell carcinoma cell lines (TT, TE2, TE6, and TE10), and determined their expression of EGFR and HER2. We examined the ability of CI-1033 to inhibit cell growth in vitro and in vivo. EGFR and HER2 were overexpressed in all 4 esophageal cancer cells. We found that CI-1033 could inhibit the growth of esophageal cancer cell lines in a dose-dependent manner with the inhibition of phosphorylation of both MAPK and AKT. The oral administration of CI-1033 exerted a significant antitumor effect on esophageal cancer tumors in athymic nude mice. Our results suggest that CI-1033 effectively inhibits the growth of esophageal squamous cell carcinoma which co-expresses both EGFR and HER2 with the inhibition of phosphorylation of both MAPK and AKT. Furthermore, in vivo animal studies of CI-1033 suggest that CI-1033 holds significant clinical potential in esophageal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Ako E, Yamashita Y, Ohira M, Yamazaki M, Hori T, Kubo N, Sawada T and Hirakawa K: The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo. Oncol Rep 17: 887-893, 2007.
APA
Ako, E., Yamashita, Y., Ohira, M., Yamazaki, M., Hori, T., Kubo, N. ... Hirakawa, K. (2007). The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo. Oncology Reports, 17, 887-893. https://doi.org/10.3892/or.17.4.887
MLA
Ako, E., Yamashita, Y., Ohira, M., Yamazaki, M., Hori, T., Kubo, N., Sawada, T., Hirakawa, K."The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo". Oncology Reports 17.4 (2007): 887-893.
Chicago
Ako, E., Yamashita, Y., Ohira, M., Yamazaki, M., Hori, T., Kubo, N., Sawada, T., Hirakawa, K."The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo". Oncology Reports 17, no. 4 (2007): 887-893. https://doi.org/10.3892/or.17.4.887
Copy and paste a formatted citation
x
Spandidos Publications style
Ako E, Yamashita Y, Ohira M, Yamazaki M, Hori T, Kubo N, Sawada T and Hirakawa K: The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo. Oncol Rep 17: 887-893, 2007.
APA
Ako, E., Yamashita, Y., Ohira, M., Yamazaki, M., Hori, T., Kubo, N. ... Hirakawa, K. (2007). The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo. Oncology Reports, 17, 887-893. https://doi.org/10.3892/or.17.4.887
MLA
Ako, E., Yamashita, Y., Ohira, M., Yamazaki, M., Hori, T., Kubo, N., Sawada, T., Hirakawa, K."The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo". Oncology Reports 17.4 (2007): 887-893.
Chicago
Ako, E., Yamashita, Y., Ohira, M., Yamazaki, M., Hori, T., Kubo, N., Sawada, T., Hirakawa, K."The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo". Oncology Reports 17, no. 4 (2007): 887-893. https://doi.org/10.3892/or.17.4.887
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