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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2009 Volume 21 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2009 Volume 21 Issue 5

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Article

Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering

  • Authors:
    • Indranil Chattopadhyay
    • Rupkumar Phukan
    • Avninder Singh
    • Madavan Vasudevan
    • Joydeep Purkayastha
    • Stephen Hewitt
    • Amal Kataki
    • Jagadish Mahanta
    • Sujala Kapur
    • Sunita Saxena

  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, Safdarjung Hospital Campus, New Delhi-110029, India
  • Pages: 1135-1146
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/or_00000333
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Abstract

To identify the genes and molecular functional pathways involved in esophageal cancer, we analyzed the gene expression profile of esophageal tumor tissue from patients having family history of esophageal cancer by cDNA microarray. Three hundred and fifty differentially expressed genes (26 up-regulated and 324 down-regulated) were identified. Genes involved in humoral immune response (PF4), extracellular matrix organization (COL4A4), metabolism of xenobiotics (EPHX1), TGF-β signaling (SMAD1) and calcium signaling pathways (VDAC1) were down-regulated and genes involved in regulation of actin cytoskeleton (WASL), neuroactive ligand receptor interaction (GRM3), Toll-like receptor (CD14), B-cell receptor (IFITM1) and insulin signaling pathways (FOXO1A) were up-regulated. Validation of differential expression of subset of genes by QRT-PCR and tissue microarray in familial and non-familial cases showed no significant difference in expression of these genes in two groups suggesting familial clustering occurs as result of sharing of common environmental factors. Gene expression profiling of clinical specimens from well characterized populations that have familial clustering of cancer identified molecular mechanism associated with progression of esophageal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Chattopadhyay I, Phukan R, Singh A, Vasudevan M, Purkayastha J, Hewitt S, Kataki A, Mahanta J, Kapur S, Saxena S, Saxena S, et al: Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering. Oncol Rep 21: 1135-1146, 2009.
APA
Chattopadhyay, I., Phukan, R., Singh, A., Vasudevan, M., Purkayastha, J., Hewitt, S. ... Saxena, S. (2009). Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering. Oncology Reports, 21, 1135-1146. https://doi.org/10.3892/or_00000333
MLA
Chattopadhyay, I., Phukan, R., Singh, A., Vasudevan, M., Purkayastha, J., Hewitt, S., Kataki, A., Mahanta, J., Kapur, S., Saxena, S."Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering". Oncology Reports 21.5 (2009): 1135-1146.
Chicago
Chattopadhyay, I., Phukan, R., Singh, A., Vasudevan, M., Purkayastha, J., Hewitt, S., Kataki, A., Mahanta, J., Kapur, S., Saxena, S."Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering". Oncology Reports 21, no. 5 (2009): 1135-1146. https://doi.org/10.3892/or_00000333
Copy and paste a formatted citation
x
Spandidos Publications style
Chattopadhyay I, Phukan R, Singh A, Vasudevan M, Purkayastha J, Hewitt S, Kataki A, Mahanta J, Kapur S, Saxena S, Saxena S, et al: Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering. Oncol Rep 21: 1135-1146, 2009.
APA
Chattopadhyay, I., Phukan, R., Singh, A., Vasudevan, M., Purkayastha, J., Hewitt, S. ... Saxena, S. (2009). Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering. Oncology Reports, 21, 1135-1146. https://doi.org/10.3892/or_00000333
MLA
Chattopadhyay, I., Phukan, R., Singh, A., Vasudevan, M., Purkayastha, J., Hewitt, S., Kataki, A., Mahanta, J., Kapur, S., Saxena, S."Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering". Oncology Reports 21.5 (2009): 1135-1146.
Chicago
Chattopadhyay, I., Phukan, R., Singh, A., Vasudevan, M., Purkayastha, J., Hewitt, S., Kataki, A., Mahanta, J., Kapur, S., Saxena, S."Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering". Oncology Reports 21, no. 5 (2009): 1135-1146. https://doi.org/10.3892/or_00000333
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