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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2009 Volume 21 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues

  • Authors:
    • Ling-Ming Tseng
    • Pen-Hui Yin
    • Yi-Fang Tsai
    • Chin-Wen Chi
    • Chew-Wun Wu
    • Liang-Ming Lee
    • Hsin-Chen Lee

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University, Taiwan 112, R.O.C.
  • Pages: 1169-1174
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/or_00000337
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Abstract

The NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme is implicated in protection against oxidative stress and carcinogenesis. NQO1 C609T genetic polymorphism was reported to be associated with an increased risk for cancers, including breast cancer. However, there is still lack of evidence whether higher oxidative stress occurs in breast tissues of patients with NQO1 609 C/T and/or T/T genotypes. Mitochondrial DNA (MtDNA) 4,977-bp deletion, the most common mutation of mtDNA, was frequently detected in post-mitotic tissues of aged subjects and associated with oxidative damage. In this study, we detected the mtDNA 4,977-bp deletion in 60 breast cancers and corresponding non-cancerous breast tissues. The incidence of the common 4,977-bp deletion in non-cancerous breast tissues (48.3%) was higher than that in breast cancer (5.0%). Moreover, 63.4% of the breast cancer patients with NQO1 C/T or T/T genotypes had the deletion in their non-cancerous breast tissues. The mtDNA deletion was more frequently detected in breast tissue of NQO1 C/T carriers (65.2%) and T/T carriers (61.1%) as compared with the NQO1 C/C carriers (15.8%, P=0.003). Similar results were observed in the <50 years old (y/o) group (P=0.06) and the ≥50 y/o group (P=0.005). Our findings suggest that mtDNA 4,977-bp deletion associated with NQO1 deficiency is involved in carcinogenesis and progression of breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Tseng L, Yin P, Tsai Y, Chi C, Wu C, Lee L and Lee H: Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues. Oncol Rep 21: 1169-1174, 2009.
APA
Tseng, L., Yin, P., Tsai, Y., Chi, C., Wu, C., Lee, L., & Lee, H. (2009). Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues. Oncology Reports, 21, 1169-1174. https://doi.org/10.3892/or_00000337
MLA
Tseng, L., Yin, P., Tsai, Y., Chi, C., Wu, C., Lee, L., Lee, H."Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues". Oncology Reports 21.5 (2009): 1169-1174.
Chicago
Tseng, L., Yin, P., Tsai, Y., Chi, C., Wu, C., Lee, L., Lee, H."Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues". Oncology Reports 21, no. 5 (2009): 1169-1174. https://doi.org/10.3892/or_00000337
Copy and paste a formatted citation
x
Spandidos Publications style
Tseng L, Yin P, Tsai Y, Chi C, Wu C, Lee L and Lee H: Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues. Oncol Rep 21: 1169-1174, 2009.
APA
Tseng, L., Yin, P., Tsai, Y., Chi, C., Wu, C., Lee, L., & Lee, H. (2009). Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues. Oncology Reports, 21, 1169-1174. https://doi.org/10.3892/or_00000337
MLA
Tseng, L., Yin, P., Tsai, Y., Chi, C., Wu, C., Lee, L., Lee, H."Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues". Oncology Reports 21.5 (2009): 1169-1174.
Chicago
Tseng, L., Yin, P., Tsai, Y., Chi, C., Wu, C., Lee, L., Lee, H."Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues". Oncology Reports 21, no. 5 (2009): 1169-1174. https://doi.org/10.3892/or_00000337
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