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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2011 Volume 25 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer

  • Authors:
    • Zhimou Xue
    • Ping Hu Sun
    • Li Ming Zhu
    • Shi Hu Jiang
    • Min Min Qiao
    • Alfred L. Chi
    • Shui Ping Tu

  • View Affiliations / Copyright

    Affiliations: Laboratory Animal Center of Soochow University, 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, P.R. China, Department of Gastroenterology, Rui-jin Hospital, Shanghai 200025, P.R. China
  • Pages: 1039-1046
    |
    Published online on: January 28, 2011
       https://doi.org/10.3892/or.2011.1166
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Abstract

Colon cancer is one of the most common cancers. Survivin is overexpressed in human colon cancer and correlate with chemoresistance, angiogenesis and poor prognosis. Oxaliplatin, a platinum derivative cancer drug, has been used for treating human colorectal cancers. In the present study, we investigated the effect of the adeno-associated virus (AAV)-mediated survivin mutant Thr34Ala [rAAV-Sur-Mut(T34A)] on colon cancer growth. Infection with rAAV-Sur-Mut(T34A) inhibited cell proliferation, induced apoptosis and mitotic catastrophe, and sensitized colon cancer cells to chemotherapeutic drugs in vitro. Treatment with rAAV-Sur-Mut(T34A) significantly induced apoptosis, reduced angiogenesis and inhibited colon cancer growth in vivo. More importantly, rAAV-Sur-Mut(T34A) treatment strongly enhanced the anti-tumor activity of oxaliplatin and prolonged animal survival. Thus, the use of rAAV-Sur-Mut(T34A) in combination with chemotherapy may be a promising strategy for colon cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Xue Z, Sun PH, Zhu LM, Jiang SH, Qiao MM, Chi AL and Tu SP: Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer. Oncol Rep 25: 1039-1046, 2011.
APA
Xue, Z., Sun, P.H., Zhu, L.M., Jiang, S.H., Qiao, M.M., Chi, A.L., & Tu, S.P. (2011). Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer. Oncology Reports, 25, 1039-1046. https://doi.org/10.3892/or.2011.1166
MLA
Xue, Z., Sun, P. H., Zhu, L. M., Jiang, S. H., Qiao, M. M., Chi, A. L., Tu, S. P."Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer". Oncology Reports 25.4 (2011): 1039-1046.
Chicago
Xue, Z., Sun, P. H., Zhu, L. M., Jiang, S. H., Qiao, M. M., Chi, A. L., Tu, S. P."Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer". Oncology Reports 25, no. 4 (2011): 1039-1046. https://doi.org/10.3892/or.2011.1166
Copy and paste a formatted citation
x
Spandidos Publications style
Xue Z, Sun PH, Zhu LM, Jiang SH, Qiao MM, Chi AL and Tu SP: Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer. Oncol Rep 25: 1039-1046, 2011.
APA
Xue, Z., Sun, P.H., Zhu, L.M., Jiang, S.H., Qiao, M.M., Chi, A.L., & Tu, S.P. (2011). Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer. Oncology Reports, 25, 1039-1046. https://doi.org/10.3892/or.2011.1166
MLA
Xue, Z., Sun, P. H., Zhu, L. M., Jiang, S. H., Qiao, M. M., Chi, A. L., Tu, S. P."Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer". Oncology Reports 25.4 (2011): 1039-1046.
Chicago
Xue, Z., Sun, P. H., Zhu, L. M., Jiang, S. H., Qiao, M. M., Chi, A. L., Tu, S. P."Adeno-associated virus-mediated survivin mutant Thr34Ala cooperates with oxaliplatin to inhibit tumor growth and angiogenesis in colon cancer". Oncology Reports 25, no. 4 (2011): 1039-1046. https://doi.org/10.3892/or.2011.1166
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